CBI Faculty publications:

The CBI faculty have an extraordinarily deep collaborative relationship with faculty throughout the University and beyond.  In fact we have active and productive collaborative relationships with groups around the world, though obviously  focused in the US.  Our role in these studies is to use our expertise in quantitative microscopy to develop experimental algorithms to solve complex scientific questions.   This generally involves probe development and selection, microscope optimization (commonly including design and machining of specialized components and programming of robotics) optimization of image collection (speed, depth, spectra and time) and downstream processing and quantitative analysis.  Essentially collaborators come to the Center with problems and leave with publishable data.  The full publication records (NCBI bibliographies) for each faculty are below

Simon Watkins Ph.D.

Donna Stolz Ph.D

Claudette M. St. Croix Ph.D.

Alan Watson Ph.D.

5 year (2013-2018) Bibliography of the CBI by Faculty

The following is a full list of each faculty’s publications for the last 5 years listed by year.

2018

1.        Zhao, J., Zhang, L., Mu, X., Doebelin, C., Nguyen, W., Wallace, C., Reay, D. P., McGowan, S. J., Corbo, L., Clemens, P. R., Wilson, G. M., Watkins, S.  C., Solt, L. A., Cameron, M. D., Huard, J., Niedernhofer, L. J., Kamenecka, T. M. & Robbins, P. D. Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-kappaB activation. PLoS biology 16, e2004663, doi:10.1371/journal.pbio.2004663 (2018).

2.        Zhang, J., Tian, X. J., Chen, Y. J., Wang, W., Watkins, S.  & Xing, J. Pathway crosstalk enables cells to interpret TGF-beta duration. NPJ systems biology and applications 4, 18, doi:10.1038/s41540-018-0060-5 (2018).

3.        Wen, X., Cui, L., Morrisroe, S., Maberry, D., Jr., Emlet, D., Watkins, S. , Hukriede, N. A. & Kellum, J. A. A zebrafish model of infection-associated acute kidney injury. American journal of physiology. Renal physiology 315, F291-f299, doi:10.1152/ajprenal.00328.2017 (2018).

4.        Waxman, S., Loewen, R. T., Dang, Y., Watkins, S.  C., Watson, A. M. & Loewen, N. A. High-Resolution, Three-Dimensional Reconstruction of the Outflow Tract Demonstrates Segmental Differences in Cleared Eyes. Investigative ophthalmology & visual science 59, 2371-2380, doi:10.1167/iovs.17-23075 (2018).

5.        Watkins, S.  C. & St Croix, C. M. Light sheet imaging comes of age. The Journal of cell biology 217, 1567-1569, doi:10.1083/jcb.201804016 (2018).

6.        Tyurina, Y. Y., Shrivastava, I., Tyurin, V. A., Mao, G., Dar, H. H., Watkins, S. , Epperly, M., Bahar, I., Shvedova, A. A., Pitt, B., Wenzel, S. E., Mallampalli, R. K., Sadovsky, Y., Gabrilovich, D., Greenberger, J. S., Bayir, H. & Kagan, V. E. "Only a Life Lived for Others Is Worth Living": Redox Signaling by Oxygenated Phospholipids in Cell Fate Decisions. Antioxidants & redox signaling 29, 1333-1358, doi:10.1089/ars.2017.7124 (2018).

7.        Sorkina, T., Ma, S., Larsen, M. B., Watkins, S.  C. & Sorkin, A. Small molecule induced oligomerization, clustering and clathrin-independent endocytosis of the dopamine transporter. eLife 7, doi:10.7554/eLife.32293 (2018).

8.        Saydmohammed, M., Yagi, H., Calderon, M., Clark, M. J., Feinstein, T., Sun, M., Stolz, D. B., Watkins, S.  C., Amack, J. D., Lo, C. W. & Tsang, M. Vertebrate myosin 1d regulates left-right organizer morphogenesis and laterality. Nature communications 9, 3381, doi:10.1038/s41467-018-05866-2 (2018).

9.        Saydmohammed, M., Vollmer, L. L., Onuoha, E. O., Maskrey, T. S., Gibson, G., Watkins, S.  C., Wipf, P., Vogt, A. & Tsang, M. A High-Content Screen Reveals New Small-Molecule Enhancers of Ras/Mapk Signaling as Probes for Zebrafish Heart Development. Molecules (Basel, Switzerland) 23, doi:10.3390/molecules23071691 (2018).

10.     Sannino, S., Guerriero, C. J., Sabnis, A. J., Stolz, D. B., Wallace, C. T., Wipf, P., Watkins, S.  C., Bivona, T. G. & Brodsky, J. L. Compensatory increases of select proteostasis networks after Hsp70 inhibition in cancer cells. Journal of cell science 131, doi:10.1242/jcs.217760 (2018).

11.     Robinson, A. R., Yousefzadeh, M. J., Rozgaja, T. A., Wang, J., Li, X., Tilstra, J. S., Feldman, C. H., Gregg, S. Q., Johnson, C. H., Skoda, E. M., Frantz, M. C., Bell-Temin, H., Pope-Varsalona, H., Gurkar, A. U., Nasto, L. A., Robinson, R. A. S., Fuhrmann-Stroissnigg, H., Czerwinska, J., McGowan, S. J., Cantu-Medellin, N., Harris, J. B., Maniar, S., Ross, M. A., Trussoni, C. E., LaRusso, N. F., Cifuentes-Pagano, E., Pagano, P. J., Tudek, B., Vo, N. V., Rigatti, L. H., Opresko, P. L., Stolz, D. B., Watkins, S.  C., Burd, C. E., Croix, C. M. S., Siuzdak, G., Yates, N. A., Robbins, P. D., Wang, Y., Wipf, P., Kelley, E. E. & Niedernhofer, L. J. Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging. Redox biology 17, 259-273, doi:10.1016/j.redox.2018.04.007 (2018).

12.     Pradhan-Sundd, T., Zhou, L., Vats, R., Jiang, A., Molina, L., Singh, S., Poddar, M., Russell, J., Stolz, D. B., Oertel, M., Apte, U., Watkins, S. , Ranganathan, S., Nejak-Bowen, K. N., Sundd, P. & Monga, S. P. Dual catenin loss in murine liver causes tight junctional deregulation and progressive intrahepatic cholestasis. Hepatology (Baltimore, Md.) 67, 2320-2337, doi:10.1002/hep.29585 (2018).

13.     Pradhan-Sundd, T., Vats, R., Russell, J. M., Singh, S., Michael, A. A., Molina, L., Kakar, S., Cornuet, P., Poddar, M., Watkins, S.  C., Nejak-Bowen, K. N., Monga, S. P. & Sundd, P. Dysregulated Bile Transporters and Impaired Tight Junctions During Chronic Liver Injury in Mice. Gastroenterology, doi:10.1053/j.gastro.2018.06.048 (2018).

14.     Perkins, L. A., Yan, Q., Schmidt, B. F., Kolodieznyi, D., Saurabh, S., Larsen, M. B., Watkins, S.  C., Kremer, L. & Bruchez, M. P. Genetically Targeted Ratiometric and Activated pH Indicator Complexes (TRApHIC) for Receptor Trafficking. Biochemistry 57, 861-871, doi:10.1021/acs.biochem.7b01135 (2018).

15.     Ning, J., Zhong, Z., Fischer, D. K., Harris, G., Watkins, S.  C., Ambrose, Z. & Zhang, P. Truncated CPSF6 Forms Higher-Order Complexes That Bind and Disrupt HIV-1 Capsid. Journal of virology 92, doi:10.1128/jvi.00368-18 (2018).

16.     Menk, A. V., Scharping, N. E., Rivadeneira, D. B., Calderon, M. J., Watson, M. J., Dunstane, D., Watkins, S.  C. & Delgoffe, G. M. 4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses. The Journal of experimental medicine 215, 1091-1100, doi:10.1084/jem.20171068 (2018).

17.     Krainz, T., Lamade, A. M., Du, L., Maskrey, T. S., Calderon, M. J., Watkins, S.  C., Epperly, M. W., Greenberger, J. S., Bayir, H., Wipf, P. & Clark, R. S. B. Synthesis and Evaluation of a Mitochondria-Targeting Poly(ADP-ribose) Polymerase-1 Inhibitor. ACS chemical biology, doi:10.1021/acschembio.8b00423 (2018).

18.     Geskin, L. J., Akilov, O. E., Kwon, S., Schowalter, M., Watkins, S. , Whiteside, T. L., Butterfield, L. H. & Falo, L. D., Jr. Therapeutic reduction of cell-mediated immunosuppression in mycosis fungoides and Sezary syndrome. Cancer immunology, immunotherapy : CII 67, 423-434, doi:10.1007/s00262-017-2090-z (2018).

19.     Duangkhae, P., Erdos, G., Ryman, K. D., Watkins, S.  C., Falo, L. D., Jr., Marques, E. T. A., Jr. & Barratt-Boyes, S. M. Interplay between Keratinocytes and Myeloid Cells Drives Dengue Virus Spread in Human Skin. The Journal of investigative dermatology 138, 618-626, doi:10.1016/j.jid.2017.10.018 (2018).

20.     Dar, H. H., Tyurina, Y. Y., Mikulska-Ruminska, K., Shrivastava, I., Ting, H. C., Tyurin, V. A., Krieger, J., St Croix, C. M., Watkins, S. , Bayir, E., Mao, G., Ambruster, C., Kapralov, A., Wang, H., Parsek, M. H., Anthonymuthu, T. S., Ogunsola, A. F., Flitter, B. A., Freedman, C. J., Gaston, J. R., Holman, T. R., Pilewski, J. M., Greenberger, J. S., Mallampalli, R. K., Doi, Y., Lee, J. S., Bahar, I., Bomberger, J. M., Bayir, H. & Kagan, V. E. Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium. The Journal of clinical investigation, doi:10.1172/jci99490 (2018).

21.     Choy, C. H., Saffi, G., Gray, M. A., Wallace, C., Dayam, R. M., Ou, Z. A., Lenk, G., Puertollano, R., Watkins, S.  C. & Botelho, R. J. Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence. Journal of cell science 131, doi:10.1242/jcs.213587 (2018).

22.     Cheng, F., Birder, L. A., Kullmann, F. A., Hornsby, J., Watton, P. N., Watkins, S. , Thompson, M. & Robertson, A. M. Layer-dependent role of collagen recruitment during loading of the rat bladder wall. Biomechanics and modeling in mechanobiology 17, 403-417, doi:10.1007/s10237-017-0968-5 (2018).

23.     Caves, E. A., Cook, S. A., Lee, N., Stoltz, D., Watkins, S.  & Shair, K. H. Y. Air-Liquid Interface Method To Study Epstein-Barr Virus Pathogenesis in Nasopharyngeal Epithelial Cells. mSphere 3, doi:10.1128/mSphere.00152-18 (2018).

24.     Cascio, S., Medsger, T. A., Jr., Hawse, W. F., Watkins, S.  C., Milcarek, C., Moreland, L. W., Lafyatis, R. A. & Fuschiotti, P. 14-3-3z sequesters cytosolic T-bet, upregulating IL-13 levels in TC2 and CD8(+) lymphocytes from patients with scleroderma. The Journal of allergy and clinical immunology 142, 109-119.e106, doi:10.1016/j.jaci.2017.10.029 (2018).

25.     Begum, G., Song, S., Wang, S., Zhao, H., Bhuiyan, M. I. H., Li, E., Nepomuceno, R., Ye, Q., Sun, M., Calderon, M. J., Stolz, D. B., St Croix, C., Watkins, S.  C., Chen, Y., He, P., Shull, G. E. & Sun, D. Selective knockout of astrocytic Na(+) /H(+) exchanger isoform 1 reduces astrogliosis, BBB damage, infarction, and improves neurological function after ischemic stroke. Glia 66, 126-144, doi:10.1002/glia.23232 (2018).

26.     Anderson, E. N., Gochenaur, L., Singh, A., Grant, R., Patel, K., Watkins, S. , Wu, J. Y. & Pandey, U. B. Traumatic injury induces stress granule formation and enhances motor dysfunctions in ALS/FTD models. Human molecular genetics 27, 1366-1381, doi:10.1093/hmg/ddy047 (2018).

 

2017

27.     Yilmaz, E., Watkins, S.  C. & Gold, M. S. Paclitaxel-induced increase in mitochondrial volume mediates dysregulation of intracellular Ca(2+) in putative nociceptive glabrous skin neurons from the rat. Cell calcium 62, 16-28, doi:10.1016/j.ceca.2017.01.005 (2017).

28.     Wenzel, S. E., Tyurina, Y. Y., Zhao, J., St Croix, C. M., Dar, H. H., Mao, G., Tyurin, V. A., Anthonymuthu, T. S., Kapralov, A. A., Amoscato, A. A., Mikulska-Ruminska, K., Shrivastava, I. H., Kenny, E. M., Yang, Q., Rosenbaum, J. C., Sparvero, L. J., Emlet, D. R., Wen, X., Minami, Y., Qu, F., Watkins, S.  C., Holman, T. R., VanDemark, A. P., Kellum, J. A., Bahar, I., Bayir, H. & Kagan, V. E. PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals. Cell 171, 628-641.e626, doi:10.1016/j.cell.2017.09.044 (2017).

29.     Weinstein, A. M., Chen, L., Brzana, E. A., Patil, P. R., Taylor, J. L., Fabian, K. L., Wallace, C. T., Jones, S. D., Watkins, S.  C., Lu, B., Stroncek, D. F., Denning, T. L., Fu, Y. X., Cohen, P. A. & Storkus, W. J. Tbet and IL-36gamma cooperate in therapeutic DC-mediated promotion of ectopic lymphoid organogenesis in the tumor microenvironment. Oncoimmunology 6, e1322238, doi:10.1080/2162402x.2017.1322238 (2017).

30.     Watson, A. M., Rose, A. H., Gibson, G. A., Gardner, C. L., Sun, C., Reed, D. S., Lam, L. K. M., St Croix, C. M., Strick, P. L., Klimstra, W. B. & Watkins, S.  C. Ribbon scanning confocal for high-speed high-resolution volume imaging of brain. PloS one 12, e0180486, doi:10.1371/journal.pone.0180486 (2017).

31.     Wang, Y., Ballou, B., Schmidt, B. F., Andreko, S., St Croix, C. M., Watkins, S.  C. & Bruchez, M. P. Affibody-targeted fluorogen activating protein for in vivo tumor imaging. Chemical communications (Cambridge, England) 53, 2001-2004, doi:10.1039/c6cc09137g (2017).

32.     Rudich, P., Snoznik, C., Watkins, S.  C., Monaghan, J., Pandey, U. B. & Lamitina, S. T. Nuclear localized C9orf72-associated arginine-containing dipeptides exhibit age-dependent toxicity in C. elegans. Human molecular genetics 26, 4916-4928, doi:10.1093/hmg/ddx372 (2017).

33.     Pinilla-Macua, I., Grassart, A., Duvvuri, U., Watkins, S.  C. & Sorkin, A. EGF receptor signaling, phosphorylation, ubiquitylation and endocytosis in tumors in vivo. eLife 6, doi:10.7554/eLife.31993 (2017).

34.     Muller, L., Simms, P., Hong, C. S., Nishimura, M. I., Jackson, E. K., Watkins, S.  C. & Whiteside, T. L. Human tumor-derived exosomes (TEX) regulate Treg functions via cell surface signaling rather than uptake mechanisms. Oncoimmunology 6, e1261243, doi:10.1080/2162402x.2016.1261243 (2017).

35.     Montecalvo, A., Watkins, S.  C., Orange, J. & Kane, L. P. Inducible turnover of optineurin regulates T cell activation. Molecular immunology 85, 9-17, doi:10.1016/j.molimm.2017.01.027 (2017).

36.     Lorenz-Guertin, J. M., Wilcox, M. R., Zhang, M., Larsen, M. B., Pilli, J., Schmidt, B. F., Bruchez, M. P., Johnson, J. W., Waggoner, A. S., Watkins, S.  C. & Jacob, T. C. A versatile optical tool for studying synaptic GABAA receptor trafficking. Journal of cell science 130, 3933-3945, doi:10.1242/jcs.205286 (2017).

37.     Liu, X., Yagi, H., Saeed, S., Bais, A. S., Gabriel, G. C., Chen, Z., Peterson, K. A., Li, Y., Schwartz, M. C., Reynolds, W. T., Saydmohammed, M., Gibbs, B., Wu, Y., Devine, W., Chatterjee, B., Klena, N. T., Kostka, D., de Mesy Bentley, K. L., Ganapathiraju, M. K., Dexheimer, P., Leatherbury, L., Khalifa, O., Bhagat, A., Zahid, M., Pu, W., Watkins, S. , Grossfeld, P., Murray, S. A., Porter, G. A., Jr., Tsang, M., Martin, L. J., Benson, D. W., Aronow, B. J. & Lo, C. W. The complex genetics of hypoplastic left heart syndrome. Nature genetics 49, 1152-1159, doi:10.1038/ng.3870 (2017).

38.     Liu, L., Kong, M., Gassman, N. R., Freudenthal, B. D., Prasad, R., Zhen, S., Watkins, S.  C., Wilson, S. H. & Van Houten, B. PARP1 changes from three-dimensional DNA damage searching to one-dimensional diffusion after auto-PARylation or in the presence of APE1. Nucleic acids research 45, 12834-12847, doi:10.1093/nar/gkx1047 (2017).

39.     Li, P., Wang, L., Zhou, Y., Gan, Y., Zhu, W., Xia, Y., Jiang, X., Watkins, S. , Vazquez, A., Thomson, A. W., Chen, J., Yu, W. & Hu, X. C-C Chemokine Receptor Type 5 (CCR5)-Mediated Docking of Transferred Tregs Protects Against Early Blood-Brain Barrier Disruption After Stroke. Journal of the American Heart Association 6, doi:10.1161/jaha.117.006387 (2017).

40.     Kagan, V. E., Mao, G., Qu, F., Angeli, J. P., Doll, S., Croix, C. S., Dar, H. H., Liu, B., Tyurin, V. A., Ritov, V. B., Kapralov, A. A., Amoscato, A. A., Jiang, J., Anthonymuthu, T., Mohammadyani, D., Yang, Q., Proneth, B., Klein-Seetharaman, J., Watkins, S. , Bahar, I., Greenberger, J., Mallampalli, R. K., Stockwell, B. R., Tyurina, Y. Y., Conrad, M. & Bayir, H. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nature chemical biology 13, 81-90, doi:10.1038/nchembio.2238 (2017).

41.     Helfield, B. L., Chen, X., Qin, B., Watkins, S.  C. & Villanueva, F. S. Mechanistic Insight into Sonoporation with Ultrasound-Stimulated Polymer Microbubbles. Ultrasound in medicine & biology 43, 2678-2689, doi:10.1016/j.ultrasmedbio.2017.07.017 (2017).

42.     Fantus, D., Dai, H., Ono, Y., Watson, A., Yokota, S., Mohib, K., Yoshida, O., Ross, M. A., Watkins, S.  C., Ramaswami, B., Valusjkikh, A., Rothstein, D. M. & Thomson, A. W. Influence of the Novel ATP-Competitive Dual mTORC1/2 Inhibitor AZD2014 on Immune Cell Populations and Heart Allograft Rejection. Transplantation 101, 2830-2840, doi:10.1097/tp.0000000000001933 (2017).

43.     Csanyi, G., Feck, D. M., Ghoshal, P., Singla, B., Lin, H., Nagarajan, S., Meijles, D. N., Al Ghouleh, I., Cantu-Medellin, N., Kelley, E. E., Mateuszuk, L., Isenberg, J. S., Watkins, S.  & Pagano, P. J. CD47 and Nox1 Mediate Dynamic Fluid-Phase Macropinocytosis of Native LDL. Antioxidants & redox signaling 26, 886-901, doi:10.1089/ars.2016.6834 (2017).

44.     Chakraborty, K., Raundhal, M., Chen, B. B., Morse, C., Tyurina, Y. Y., Khare, A., Oriss, T. B., Huff, R., Lee, J. S., St Croix, C. M., Watkins, S. , Mallampalli, R. K., Kagan, V. E., Ray, A. & Ray, P. The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia. Nature communications 8, 13944, doi:10.1038/ncomms13944 (2017).

45.     Akiyama, H., Ramirez, N. P., Gibson, G., Kline, C., Watkins, S. , Ambrose, Z. & Gummuluru, S. Interferon-Inducible CD169/Siglec1 Attenuates Anti-HIV-1 Effects of Alpha Interferon. Journal of virology 91, doi:10.1128/jvi.00972-17 (2017).

 

2016

46.     Zerbato, J. M., Serrao, E., Lenzi, G., Kim, B., Ambrose, Z., Watkins, S.  C., Engelman, A. N. & Sluis-Cremer, N. Establishment and Reversal of HIV-1 Latency in Naive and Central Memory CD4+ T Cells In Vitro. Journal of virology 90, 8059-8073, doi:10.1128/jvi.00553-16 (2016).

47.     Tsamis, A., Phillippi, J. A., Koch, R. G., Chan, P. G., Krawiec, J. T., D'Amore, A., Watkins, S.  C., Wagner, W. R., Vorp, D. A. & Gleason, T. G. Extracellular matrix fiber microarchitecture is region-specific in bicuspid aortic valve-associated ascending aortopathy. The Journal of thoracic and cardiovascular surgery 151, 1718-1728.e1715, doi:10.1016/j.jtcvs.2016.02.019 (2016).

48.     Sparvero, L. J., Amoscato, A. A., Fink, A. B., Anthonymuthu, T., New, L. A., Kochanek, P. M., Watkins, S. , Kagan, V. E. & Bayir, H. Imaging mass spectrometry reveals loss of polyunsaturated cardiolipins in the cortical contusion, hippocampus, and thalamus after traumatic brain injury. Journal of neurochemistry 139, 659-675, doi:10.1111/jnc.13840 (2016).

49.     Sehrawat, A., Croix, C. S., Baty, C. J., Watkins, S. , Tailor, D., Singh, R. P. & Singh, S. V. Inhibition of mitochondrial fusion is an early and critical event in breast cancer cell apoptosis by dietary chemopreventative benzyl isothiocyanate. Mitochondrion 30, 67-77, doi:10.1016/j.mito.2016.06.006 (2016).

50.     Scharping, N. E., Menk, A. V., Moreci, R. S., Whetstone, R. D., Dadey, R. E., Watkins, S.  C., Ferris, R. L. & Delgoffe, G. M. The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction. Immunity 45, 374-388, doi:10.1016/j.immuni.2016.07.009 (2016).

51.     Pinilla-Macua, I., Watkins, S.  C. & Sorkin, A. Endocytosis separates EGF receptors from endogenous fluorescently labeled HRas and diminishes receptor signaling to MAP kinases in endosomes. Proceedings of the National Academy of Sciences of the United States of America 113, 2122-2127, doi:10.1073/pnas.1520301113 (2016).

52.     Pasta, S., Phillippi, J. A., Tsamis, A., D'Amore, A., Raffa, G. M., Pilato, M., Scardulla, C., Watkins, S.  C., Wagner, W. R., Gleason, T. G. & Vorp, D. A. Constitutive modeling of ascending thoracic aortic aneurysms using microstructural parameters. Medical engineering & physics 38, 121-130, doi:10.1016/j.medengphy.2015.11.001 (2016).

53.     Osei-Hwedieh, D. O., Kanias, T., Croix, C. S., Jessup, M., Xiong, Z., Sinchar, D., Franks, J., Xu, Q., E, M. N., Sertorio, J. T., Potoka, K., Binder, R. J., Basu, S., Belanger, A. M., Kim-Shapiro, D. B., Triulzi, D., Lee, J. S. & Gladwin, M. T. Sickle Cell Trait Increases Red Blood Cell Storage Hemolysis and Post-Transfusion Clearance in Mice. EBioMedicine 11, 239-248, doi:10.1016/j.ebiom.2016.08.006 (2016).

54.     Ma, L., Umasankar, P. K., Wrobel, A. G., Lymar, A., McCoy, A. J., Holkar, S. S., Jha, A., Pradhan-Sundd, T., Watkins, S.  C., Owen, D. J. & Traub, L. M. Transient Fcho1/2Eps15/RAP-2 Nanoclusters Prime the AP-2 Clathrin Adaptor for Cargo Binding. Developmental cell 37, 428-443, doi:10.1016/j.devcel.2016.05.003 (2016).

55.     Liu, Q., Rojas-Canales, D. M., Divito, S. J., Shufesky, W. J., Stolz, D. B., Erdos, G., Sullivan, M. L., Gibson, G. A., Watkins, S.  C., Larregina, A. T. & Morelli, A. E. Donor dendritic cell-derived exosomes promote allograft-targeting immune response. The Journal of clinical investigation 126, 2805-2820, doi:10.1172/jci84577 (2016).

56.     Larsen, M. B., Hu, J., Frizzell, R. A. & Watkins, S.  C. Simple image-based no-wash method for quantitative detection of surface expressed CFTR. Methods (San Diego, Calif.) 96, 40-45, doi:10.1016/j.ymeth.2015.09.006 (2016).

57.     Kong, M., Liu, L., Chen, X., Driscoll, K. I., Mao, P., Bohm, S., Kad, N. M., Watkins, S.  C., Bernstein, K. A., Wyrick, J. J., Min, J. H. & Van Houten, B. Single-Molecule Imaging Reveals that Rad4 Employs a Dynamic DNA Damage Recognition Process. Molecular cell 64, 376-387, doi:10.1016/j.molcel.2016.09.005 (2016).

58.     Klei, L. R., Hu, D., Panek, R., Alfano, D. N., Bridwell, R. E., Bailey, K. M., Oravecz-Wilson, K. I., Concel, V. J., Hess, E. M., Van Beek, M., Delekta, P. C., Gu, S., Watkins, S.  C., Ting, A. T., Gough, P. J., Foley, K. P., Bertin, J., McAllister-Lucas, L. M. & Lucas, P. C. MALT1 Protease Activation Triggers Acute Disruption of Endothelial Barrier Integrity via CYLD Cleavage. Cell reports 17, 221-232, doi:10.1016/j.celrep.2016.08.080 (2016).

59.     Khare, A., Raundhal, M., Chakraborty, K., Das, S., Corey, C., Kamga, C. K., Quesnelle, K., St Croix, C., Watkins, S.  C., Morse, C., Oriss, T. B., Huff, R., Hannum, R., Ray, P., Shiva, S. & Ray, A. Mitochondrial H2O2 in Lung Antigen-Presenting Cells Blocks NF-kappaB Activation to Prevent Unwarranted Immune Activation. Cell reports 15, 1700-1714, doi:10.1016/j.celrep.2016.04.060 (2016).

60.     Keskinov, A. A., Tapias, V., Watkins, S.  C., Ma, Y., Shurin, M. R. & Shurin, G. V. Impact of the Sensory Neurons on Melanoma Growth In Vivo. PloS one 11, e0156095, doi:10.1371/journal.pone.0156095 (2016).

61.     Kagan, V. E., Jiang, J., Huang, Z., Tyurina, Y. Y., Desbourdes, C., Cottet-Rousselle, C., Dar, H. H., Verma, M., Tyurin, V. A., Kapralov, A. A., Cheikhi, A., Mao, G., Stolz, D., St Croix, C. M., Watkins, S. , Shen, Z., Li, Y., Greenberg, M. L., Tokarska-Schlattner, M., Boissan, M., Lacombe, M. L., Epand, R. M., Chu, C. T., Mallampalli, R. K., Bayir, H. & Schlattner, U. NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy. Cell death and differentiation 23, 1140-1151, doi:10.1038/cdd.2015.160 (2016).

62.     Huang, Z., Epperly, M., Watkins, S.  C., Greenberger, J. S., Kagan, V. E. & Bayir, H. Necrostatin-1 rescues mice from lethal irradiation. Biochimica et biophysica acta 1862, 850-856, doi:10.1016/j.bbadis.2016.01.014 (2016).

63.     Helfield, B., Chen, X., Watkins, S.  C. & Villanueva, F. S. Biophysical insight into mechanisms of sonoporation. Proceedings of the National Academy of Sciences of the United States of America 113, 9983-9988, doi:10.1073/pnas.1606915113 (2016).

64.     He, J., Wang, Y., Missinato, M. A., Onuoha, E., Perkins, L. A., Watkins, S.  C., St Croix, C. M., Tsang, M. & Bruchez, M. P. A genetically targetable near-infrared photosensitizer. Nature methods 13, 263-268, doi:10.1038/nmeth.3735 (2016).

65.     Garcia-Exposito, L., Bournique, E., Bergoglio, V., Bose, A., Barroso-Gonzalez, J., Zhang, S., Roncaioli, J. L., Lee, M., Wallace, C. T., Watkins, S.  C., Opresko, P. L., Hoffmann, J. S. & O'Sullivan, R. J. Proteomic Profiling Reveals a Specific Role for Translesion DNA Polymerase eta in the Alternative Lengthening of Telomeres. Cell reports 17, 1858-1871, doi:10.1016/j.celrep.2016.10.048 (2016).

66.     Dukes, A. A., Bai, Q., Van Laar, V. S., Zhou, Y., Ilin, V., David, C. N., Agim, Z. S., Bonkowsky, J. L., Cannon, J. R., Watkins, S.  C., Croix, C. M., Burton, E. A. & Berman, S. B. Live imaging of mitochondrial dynamics in CNS dopaminergic neurons in vivo demonstrates early reversal of mitochondrial transport following MPP(+) exposure. Neurobiology of disease 95, 238-249, doi:10.1016/j.nbd.2016.07.020 (2016).

67.     Dezfulian, C., Kenny, E., Lamade, A., Misse, A., Krehel, N., St Croix, C., Kelley, E. E., Jackson, T. C., Uray, T., Rackley, J., Kochanek, P. M., Clark, R. S. & Bayir, H. Mechanistic characterization of nitrite-mediated neuroprotection after experimental cardiac arrest. Journal of neurochemistry 139, 419-431, doi:10.1111/jnc.13764 (2016).

 

2015

68.     Zaccard, C. R., Watkins, S.  C., Kalinski, P., Fecek, R. J., Yates, A. L., Salter, R. D., Ayyavoo, V., Rinaldo, C. R. & Mailliard, R. B. CD40L induces functional tunneling nanotube networks exclusively in dendritic cells programmed by mediators of type 1 immunity. Journal of immunology (Baltimore, Md. : 1950) 194, 1047-1056, doi:10.4049/jimmunol.1401832 (2015).

69.     Xu, J., Benabou, K., Cui, X., Madia, M., Tzeng, E., Billiar, T., Watkins, S.  & Sachdev, U. TLR4 Deters Perfusion Recovery and Upregulates Toll-like Receptor 2 (TLR2) in Ischemic Skeletal Muscle and Endothelial Cells. Molecular medicine (Cambridge, Mass.) 21, 605-615, doi:10.2119/molmed.2014.00260 (2015).

70.     Wallace, C. T., St Croix, C. M. & Watkins, S.  C. Data management and archiving in a large microscopy-and-imaging, multi-user facility: Problems and solutions. Molecular reproduction and development 82, 630-634, doi:10.1002/mrd.22538 (2015).

71.     Vogel, S., Bodenstein, R., Chen, Q., Feil, S., Feil, R., Rheinlaender, J., Schaffer, T. E., Bohn, E., Frick, J. S., Borst, O., Munzer, P., Walker, B., Markel, J., Csanyi, G., Pagano, P. J., Loughran, P., Jessup, M. E., Watkins, S.  C., Bullock, G. C., Sperry, J. L., Zuckerbraun, B. S., Billiar, T. R., Lotze, M. T., Gawaz, M. & Neal, M. D. Platelet-derived HMGB1 is a critical mediator of thrombosis. The Journal of clinical investigation 125, 4638-4654, doi:10.1172/jci81660 (2015).

72.     Robertson, A. M., Duan, X., Aziz, K. M., Hill, M. R., Watkins, S.  C. & Cebral, J. R. Diversity in the Strength and Structure of Unruptured Cerebral Aneurysms. Annals of biomedical engineering 43, 1502-1515, doi:10.1007/s10439-015-1252-4 (2015).

73.     Reichenbach, D. K., Schwarze, V., Matta, B. M., Tkachev, V., Lieberknecht, E., Liu, Q., Koehn, B. H., Pfeifer, D., Taylor, P. A., Prinz, G., Dierbach, H., Stickel, N., Beck, Y., Warncke, M., Junt, T., Schmitt-Graeff, A., Nakae, S., Follo, M., Wertheimer, T., Schwab, L., Devlin, J., Watkins, S.  C., Duyster, J., Ferrara, J. L., Turnquist, H. R., Zeiser, R. & Blazar, B. R. The IL-33/ST2 axis augments effector T-cell responses during acute GVHD. Blood 125, 3183-3192, doi:10.1182/blood-2014-10-606830 (2015).

74.     Rastede, E. E., Tanha, M., Yaron, D., Watkins, S.  C., Waggoner, A. S. & Armitage, B. A. Spectral fine tuning of cyanine dyes: electron donor-acceptor substituted analogues of thiazole orange. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 14, 1703-1712, doi:10.1039/c5pp00117j (2015).

75.     Phong, B. L., Avery, L., Sumpter, T. L., Gorman, J. V., Watkins, S.  C., Colgan, J. D. & Kane, L. P. Tim-3 enhances FcepsilonRI-proximal signaling to modulate mast cell activation. The Journal of experimental medicine 212, 2289-2304, doi:10.1084/jem.20150388 (2015).

76.     Phinney, D. G., Di Giuseppe, M., Njah, J., Sala, E., Shiva, S., St Croix, C. M., Stolz, D. B., Watkins, S.  C., Di, Y. P., Leikauf, G. D., Kolls, J., Riches, D. W., Deiuliis, G., Kaminski, N., Boregowda, S. V., McKenna, D. H. & Ortiz, L. A. Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs. Nature communications 6, 8472, doi:10.1038/ncomms9472 (2015).

77.     Peifer, M., Hertwig, F., Roels, F., Dreidax, D., Gartlgruber, M., Menon, R., Kramer, A., Roncaioli, J. L., Sand, F., Heuckmann, J. M., Ikram, F., Schmidt, R., Ackermann, S., Engesser, A., Kahlert, Y., Vogel, W., Altmuller, J., Nurnberg, P., Thierry-Mieg, J., Thierry-Mieg, D., Mariappan, A., Heynck, S., Mariotti, E., Henrich, K. O., Gloeckner, C., Bosco, G., Leuschner, I., Schweiger, M. R., Savelyeva, L., Watkins, S.  C., Shao, C., Bell, E., Hofer, T., Achter, V., Lang, U., Theissen, J., Volland, R., Saadati, M., Eggert, A., de Wilde, B., Berthold, F., Peng, Z., Zhao, C., Shi, L., Ortmann, M., Buttner, R., Perner, S., Hero, B., Schramm, A., Schulte, J. H., Herrmann, C., O'Sullivan, R. J., Westermann, F., Thomas, R. K. & Fischer, M. Telomerase activation by genomic rearrangements in high-risk neuroblastoma. Nature 526, 700-704, doi:10.1038/nature14980 (2015).

78.     Pardee, A. D., Yano, H., Weinstein, A. M., Ponce, A. A., Ethridge, A. D., Normolle, D. P., Vujanovic, L., Mizejewski, G. J., Watkins, S.  C. & Butterfield, L. H. Route of antigen delivery impacts the immunostimulatory activity of dendritic cell-based vaccines for hepatocellular carcinoma. Journal for immunotherapy of cancer 3, 32, doi:10.1186/s40425-015-0077-x (2015).

79.     Hemmasizadeh, A., Tsamis, A., Cheheltani, R., Assari, S., D'Amore, A., Autieri, M., Kiani, M. F., Pleshko, N., Wagner, W. R., Watkins, S.  C., Vorp, D. & Darvish, K. Correlations between transmural mechanical and morphological properties in porcine thoracic descending aorta. Journal of the mechanical behavior of biomedical materials 47, 12-20, doi:10.1016/j.jmbbm.2015.03.004 (2015).

80.     Fortian, A., Dionne, L. K., Hong, S. H., Kim, W., Gygi, S. P., Watkins, S.  C. & Sorkin, A. Endocytosis of Ubiquitylation-Deficient EGFR Mutants via Clathrin-Coated Pits is Mediated by Ubiquitylation. Traffic (Copenhagen, Denmark) 16, 1137-1154, doi:10.1111/tra.12314 (2015).

81.     Connolly, R. M., Leal, J. P., Goetz, M. P., Zhang, Z., Zhou, X. C., Jacobs, L. K., Mhlanga, J., O, J. H., Carpenter, J., Storniolo, A. M., Watkins, S. , Fetting, J. H., Miller, R. S., Sideras, K., Jeter, S. C., Walsh, B., Powers, P., Zorzi, J., Boughey, J. C., Davidson, N. E., Carey, L. A., Wolff, A. C., Khouri, N., Gabrielson, E., Wahl, R. L. & Stearns, V. TBCRC 008: early change in 18F-FDG uptake on PET predicts response to preoperative systemic therapy in human epidermal growth factor receptor 2-negative primary operable breast cancer. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 56, 31-37, doi:10.2967/jnumed.114.144741 (2015).

82.     Chen, M., Tian, S., Glasgow, N. G., Gibson, G., Yang, X., Shiber, C. E., Funderburgh, J., Watkins, S. , Johnson, J. W., Schuman, J. S. & Liu, H. Lgr5(+) amacrine cells possess regenerative potential in the retina of adult mice. Aging cell 14, 635-643, doi:10.1111/acel.12346 (2015).

83.     Block, E. R., Nuttle, J., Balcita-Pedicino, J. J., Caltagarone, J., Watkins, S.  C., Sesack, S. R. & Sorkin, A. Brain Region-Specific Trafficking of the Dopamine Transporter. The Journal of neuroscience : the official journal of the Society for Neuroscience 35, 12845-12858, doi:10.1523/jneurosci.1391-15.2015 (2015).

84.     Balasubramanian, K., Maeda, A., Lee, J. S., Mohammadyani, D., Dar, H. H., Jiang, J. F., St Croix, C. M., Watkins, S. , Tyurin, V. A., Tyurina, Y. Y., Kloditz, K., Polimova, A., Kapralova, V. I., Xiong, Z., Ray, P., Klein-Seetharaman, J., Mallampalli, R. K., Bayir, H., Fadeel, B. & Kagan, V. E. Dichotomous roles for externalized cardiolipin in extracellular signaling: Promotion of phagocytosis and attenuation of innate immunity. Science signaling 8, ra95, doi:10.1126/scisignal.aaa6179 (2015).

 

2014

85.     Zaccard, C. R., Watkins, S.  C., Ayyavoo, V., Rinaldo, C. R. & Mailliard, R. B. HIV's ticket to ride: Cytotoxic T-lymphocyte-activated dendritic cells exploited for virus intercellular transfer. AIDS research and human retroviruses 30, 1023-1024, doi:10.1089/aid.2014.0218 (2014).

86.     Wheeler, S. E., Shi, H., Lin, F., Dasari, S., Bednash, J., Thorne, S., Watkins, S. , Joshi, R. & Thomas, S. M. Enhancement of head and neck squamous cell carcinoma proliferation, invasion, and metastasis by tumor-associated fibroblasts in preclinical models. Head & neck 36, 385-392, doi:10.1002/hed.23312 (2014).

87.     Umasankar, P. K., Ma, L., Thieman, J. R., Jha, A., Doray, B., Watkins, S.  C. & Traub, L. M. A clathrin coat assembly role for the muniscin protein central linker revealed by TALEN-mediated gene editing. eLife 3, doi:10.7554/eLife.04137 (2014).

88.     Stoyanovsky, D. A., Sparvero, L. J., Amoscato, A. A., He, R. R., Watkins, S. , Pitt, B. R., Bayir, H. & Kagan, V. E. Improved spatial resolution of matrix-assisted laser desorption/ionization imaging of lipids in the brain by alkylated derivatives of 2,5-dihydroxybenzoic acid. Rapid communications in mass spectrometry : RCM 28, 403-412, doi:10.1002/rcm.6796 (2014).

89.     Shao, H., Li, S., Watkins, S.  C. & Wells, A. alpha-Actinin-4 is required for amoeboid-type invasiveness of melanoma cells. The Journal of biological chemistry 289, 32717-32728, doi:10.1074/jbc.M114.579185 (2014).

90.     Saurabh, S., Beck, L. E., Maji, S., Baty, C. J., Wang, Y., Yan, Q., Watkins, S.  C. & Bruchez, M. P. Multiplexed modular genetic targeting of quantum dots. ACS nano 8, 11138-11146, doi:10.1021/nn5044367 (2014).

91.     Phillippi, J. A., Green, B. R., Eskay, M. A., Kotlarczyk, M. P., Hill, M. R., Robertson, A. M., Watkins, S.  C., Vorp, D. A. & Gleason, T. G. Mechanism of aortic medial matrix remodeling is distinct in patients with bicuspid aortic valve. The Journal of thoracic and cardiovascular surgery 147, 1056-1064, doi:10.1016/j.jtcvs.2013.04.028 (2014).

92.     Ohkuri, T., Ghosh, A., Kosaka, A., Zhu, J., Ikeura, M., David, M., Watkins, S.  C., Sarkar, S. N. & Okada, H. STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment. Cancer immunology research 2, 1199-1208, doi:10.1158/2326-6066.Cir-14-0099 (2014).

93.     Muller, L., Hong, C. S., Stolz, D. B., Watkins, S.  C. & Whiteside, T. L. Isolation of biologically-active exosomes from human plasma. Journal of immunological methods 411, 55-65, doi:10.1016/j.jim.2014.06.007 (2014).

94.     Luke, C. J., Niehaus, J. Z., O'Reilly, L. P. & Watkins, S.  C. Non-microfluidic methods for imaging live C. elegans. Methods (San Diego, Calif.) 68, 542-547, doi:10.1016/j.ymeth.2014.05.002 (2014).

95.     Long, O. S., Benson, J. A., Kwak, J. H., Luke, C. J., Gosai, S. J., O'Reilly, L. P., Wang, Y., Li, J., Vetica, A. C., Miedel, M. T., Stolz, D. B., Watkins, S.  C., Zuchner, S., Perlmutter, D. H., Silverman, G. A. & Pak, S. C. A C. elegans model of human alpha1-antitrypsin deficiency links components of the RNAi pathway to misfolded protein turnover. Human molecular genetics 23, 5109-5122, doi:10.1093/hmg/ddu235 (2014).

96.     Lin, J., Countryman, P., Buncher, N., Kaur, P., E, L., Zhang, Y., Gibson, G., You, C., Watkins, S.  C., Piehler, J., Opresko, P. L., Kad, N. M. & Wang, H. TRF1 and TRF2 use different mechanisms to find telomeric DNA but share a novel mechanism to search for protein partners at telomeres. Nucleic acids research 42, 2493-2504, doi:10.1093/nar/gkt1132 (2014).

97.     Koch, R. G., Tsamis, A., D'Amore, A., Wagner, W. R., Watkins, S.  C., Gleason, T. G. & Vorp, D. A. A custom image-based analysis tool for quantifying elastin and collagen micro-architecture in the wall of the human aorta from multi-photon microscopy. Journal of biomechanics 47, 935-943, doi:10.1016/j.jbiomech.2014.01.027 (2014).

98.     Klinkenberg, D., Long, K. R., Shome, K., Watkins, S.  C. & Aridor, M. A cascade of ER exit site assembly that is regulated by p125A and lipid signals. Journal of cell science 127, 1765-1778, doi:10.1242/jcs.138784 (2014).

99.     Kelley, E. E., Baust, J., Bonacci, G., Golin-Bisello, F., Devlin, J. E., St Croix, C. M., Watkins, S.  C., Gor, S., Cantu-Medellin, N., Weidert, E. R., Frisbee, J. C., Gladwin, M. T., Champion, H. C., Freeman, B. A. & Khoo, N. K. Fatty acid nitroalkenes ameliorate glucose intolerance and pulmonary hypertension in high-fat diet-induced obesity. Cardiovascular research 101, 352-363, doi:10.1093/cvr/cvt341 (2014).

100.  Kagan, V. E., Kapralov, A. A., St Croix, C. M., Watkins, S.  C., Kisin, E. R., Kotchey, G. P., Balasubramanian, K., Vlasova, II, Yu, J., Kim, K., Seo, W., Mallampalli, R. K., Star, A. & Shvedova, A. A. Lung macrophages "digest" carbon nanotubes using a superoxide/peroxynitrite oxidative pathway. ACS nano 8, 5610-5621, doi:10.1021/nn406484b (2014).

101.  Han, J., Hou, W., Goldstein, L. A., Stolz, D. B., Watkins, S.  C. & Rabinowich, H. A Complex between Atg7 and Caspase-9: A NOVEL MECHANISM OF CROSS-REGULATION BETWEEN AUTOPHAGY AND APOPTOSIS. The Journal of biological chemistry 289, 6485-6497, doi:10.1074/jbc.M113.536854 (2014).

102.  Hadi, K., Walker, L. A., Guha, D., Murali, R., Watkins, S.  C., Tarwater, P., Srinivasan, A. & Ayyavoo, V. Human immunodeficiency virus type 1 Vpr polymorphisms associated with progressor and nonprogressor individuals alter Vpr-associated functions. The Journal of general virology 95, 700-711, doi:10.1099/vir.0.059576-0 (2014).

103.  Ghodke, H., Wang, H., Hsieh, C. L., Woldemeskel, S., Watkins, S.  C., Rapic-Otrin, V. & Van Houten, B. Single-molecule analysis reveals human UV-damaged DNA-binding protein (UV-DDB) dimerizes on DNA via multiple kinetic intermediates. Proceedings of the National Academy of Sciences of the United States of America 111, E1862-1871, doi:10.1073/pnas.1323856111 (2014).

104.  Fazzi, F., Njah, J., Di Giuseppe, M., Winnica, D. E., Go, K., Sala, E., St Croix, C. M., Watkins, S.  C., Tyurin, V. A., Phinney, D. G., Fattman, C. L., Leikauf, G. D., Kagan, V. E. & Ortiz, L. A. TNFR1/phox interaction and TNFR1 mitochondrial translocation Thwart silica-induced pulmonary fibrosis. Journal of immunology (Baltimore, Md. : 1950) 192, 3837-3846, doi:10.4049/jimmunol.1103516 (2014).

105.  D'Amore, A., Amoroso, N., Gottardi, R., Hobson, C., Carruthers, C., Watkins, S. , Wagner, W. R. & Sacks, M. S. From single fiber to macro-level mechanics: A structural finite-element model for elastomeric fibrous biomaterials. Journal of the mechanical behavior of biomedical materials 39, 146-161, doi:10.1016/j.jmbbm.2014.07.016 (2014).

106.  Conti, H. R., Peterson, A. C., Brane, L., Huppler, A. R., Hernandez-Santos, N., Whibley, N., Garg, A. V., Simpson-Abelson, M. R., Gibson, G. A., Mamo, A. J., Osborne, L. C., Bishu, S., Ghilardi, N., Siebenlist, U., Watkins, S.  C., Artis, D., McGeachy, M. J. & Gaffen, S. L. Oral-resident natural Th17 cells and gammadelta T cells control opportunistic Candida albicans infections. The Journal of experimental medicine 211, 2075-2084, doi:10.1084/jem.20130877 (2014).

107.  Chakraborty, S., Umasankar, P. K., Preston, G. M., Khandelwal, P., Apodaca, G., Watkins, S.  C. & Traub, L. M. A phosphotyrosine switch for cargo sequestration at clathrin-coated buds. The Journal of biological chemistry 289, 17497-17514, doi:10.1074/jbc.M114.556589 (2014).

108.  Bennewitz, M. F., Watkins, S.  C. & Sundd, P. Quantitative intravital two-photon excitation microscopy reveals absence of pulmonary vaso-occlusion in unchallenged Sickle Cell Disease mice. Intravital 3, e29748, doi:10.4161/intv.29748 (2014).

109.  Amoscato, A. A., Sparvero, L. J., He, R. R., Watkins, S. , Bayir, H. & Kagan, V. E. Imaging mass spectrometry of diversified cardiolipin molecular species in the brain. Analytical chemistry 86, 6587-6595, doi:10.1021/ac5011876 (2014).

 

Claudette M. St. Croix Ph.D.

2018

1       Watkins, S. C. & St Croix, C. M. Light sheet imaging comes of age. J Cell Biol 217, 1567-1569, doi:10.1083/jcb.201804016 (2018).

2       Van Laar, V. S., Arnold, B., Howlett, E. H., Calderon, M. J., St Croix, C. M., Greenamyre, J. T., Sanders, L. H. & Berman, S. B. Evidence for Compartmentalized Axonal Mitochondrial Biogenesis: Mitochondrial DNA Replication Increases in Distal Axons As an Early Response to Parkinson's Disease-Relevant Stress. J Neurosci 38, 7505-7515, doi:10.1523/JNEUROSCI.0541-18.2018 (2018).

3       Dar, H. H., Tyurina, Y. Y., Mikulska-Ruminska, K., Shrivastava, I., Ting, H. C., Tyurin, V. A., Krieger, J., St Croix, C. M., Watkins, S., Bayir, E., Mao, G., Ambruster, C., Kapralov, A., Wang, H., Parsek, M. H., Anthonymuthu, T. S., Ogunsola, A. F., Flitter, B. A., Freedman, C. J., Gaston, J. R., Holman, T. R., Pilewski, J. M., Greenberger, J. S., Mallampalli, R. K., Doi, Y., Lee, J. S., Bahar, I., Bomberger, J. M., Bayir, H. & Kagan, V. E. Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium. J Clin Invest, doi:10.1172/JCI99490 (2018).

4       Bueno, M., Brands, J., Voltz, L., Fiedler, K., Mays, B., St Croix, C., Sembrat, J., Mallampalli, R. K., Rojas, M. & Mora, A. L. ATF3 represses PINK1 gene transcription in lung epithelial cells to control mitochondrial homeostasis. Aging Cell 17, doi:10.1111/acel.12720 (2018).

5       Begum, G., Song, S., Wang, S., Zhao, H., Bhuiyan, M. I. H., Li, E., Nepomuceno, R., Ye, Q., Sun, M., Calderon, M. J., Stolz, D. B., St Croix, C., Watkins, S. C., Chen, Y., He, P., Shull, G. E. & Sun, D. Selective knockout of astrocytic Na(+) /H(+) exchanger isoform 1 reduces astrogliosis, BBB damage, infarction, and improves neurological function after ischemic stroke. Glia 66, 126-144, doi:10.1002/glia.23232 (2018).

6       Gurkar AU, Robinson AR, Cui Y, Li X, Allani SK, Webster A, Muravia M, Fallahi M, Weissbach H, Robbins PD, Wang Y, Kelley EE, St Croix CM, Niedernhofer LJ, Gill MS. Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging. Redox Biol. 2018 Sep;18:191-199. doi: 10.1016/j.redox.2018.06.005. Epub 2018 Jun 19. PubMed PMID: 30031267; PubMedCentral PMCID: PMC6076207.

7       Robinson AR, Yousefzadeh MJ, Rozgaja TA, Wang J, Li X, Tilstra JS, Feldman CH, Gregg SQ, Johnson CH, Skoda EM, Frantz MC, Bell-Temin H, Pope-Varsalona H, Gurkar AU, Nasto LA, Robinson RAS, Fuhrmann-Stroissnigg H, Czerwinska J, McGowan SJ, Cantu-Medellin N, Harris JB, Maniar S, Ross MA, Trussoni CE, LaRusso NF, Cifuentes-Pagano E, Pagano PJ, Tudek B, Vo NV, Rigatti LH, Opresko PL, Stolz DB, Watkins SC, Burd CE, St Croix CM, Siuzdak G, Yates NA, Robbins PD, Wang Y, Wipf P, Kelley EE, Niedernhofer LJ. Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging. Redox Biol. 2018 Jul;17:259-273. doi: 10.1016/j.redox.2018.04.007. Epub 2018 Apr 13. PubMed PMID: 29747066; PubMed Central PMCID: PMC6006678.

2017

6       Zhao, J., Fuhrmann-Stroissnigg, H., Gurkar, A. U., Flores, R. R., Dorronsoro, A., Stolz, D. B., St Croix, C. M., Niedernhofer, L. J. & Robbins, P. D. Quantitative Analysis of Cellular Senescence in Culture and In Vivo. Curr Protoc Cytom 79, 9 51 51-59 51 25, doi:10.1002/cpcy.16 (2017).

7       Wesolowski, J., Weber, M. M., Nawrotek, A., Dooley, C. A., Calderon, M., St Croix, C. M., Hackstadt, T., Cherfils, J. & Paumet, F. Chlamydia Hijacks ARF GTPases To Coordinate Microtubule Posttranslational Modifications and Golgi Complex Positioning. MBio 8, doi:10.1128/mBio.02280-16 (2017).

8       Wenzel, S. E., Tyurina, Y. Y., Zhao, J., St Croix, C. M., Dar, H. H., Mao, G., Tyurin, V. A., Anthonymuthu, T. S., Kapralov, A. A., Amoscato, A. A., Mikulska-Ruminska, K., Shrivastava, I. H., Kenny, E. M., Yang, Q., Rosenbaum, J. C., Sparvero, L. J., Emlet, D. R., Wen, X., Minami, Y., Qu, F., Watkins, S. C., Holman, T. R., VanDemark, A. P., Kellum, J. A., Bahar, I., Bayir, H. & Kagan, V. E. PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals. Cell 171, 628-641 e626, doi:10.1016/j.cell.2017.09.044 (2017).

9       Watson, A. M., Rose, A. H., Gibson, G. A., Gardner, C. L., Sun, C., Reed, D. S., Lam, L. K. M., St Croix, C. M., Strick, P. L., Klimstra, W. B. & Watkins, S. C. Ribbon scanning confocal for high-speed high-resolution volume imaging of brain. PLoS One 12, e0180486, doi:10.1371/journal.pone.0180486 (2017).

10     Wang, Y., Ballou, B., Schmidt, B. F., Andreko, S., St Croix, C. M., Watkins, S. C. & Bruchez, M. P. Affibody-targeted fluorogen activating protein for in vivo tumor imaging. Chem Commun (Camb) 53, 2001-2004, doi:10.1039/c6cc09137g (2017).

11     Rogers, N. M., Sharifi-Sanjani, M., Yao, M., Ghimire, K., Bienes-Martinez, R., Mutchler, S. M., Knupp, H. E., Baust, J., Novelli, E. M., Ross, M., St Croix, C., Kutten, J. C., Czajka, C. A., Sembrat, J. C., Rojas, M., Labrousse-Arias, D., Bachman, T. N., Vanderpool, R. R., Zuckerbraun, B. S., Champion, H. C., Mora, A. L., Straub, A. C., Bilonick, R. A., Calzada, M. J. & Isenberg, J. S. TSP1-CD47 signaling is upregulated in clinical pulmonary hypertension and contributes to pulmonary arterial vasculopathy and dysfunction. Cardiovasc Res 113, 15-29, doi:10.1093/cvr/cvw218 (2017).

12     Li, L., Poloyac, S. M., Watkins, S. C., St Croix, C. M., Alexander, H., Gibson, G. A., Loughran, P. A., Kirisci, L., Clark, R. S., Kochanek, P. M., Vazquez, A. L. & Manole, M. D. Cerebral microcirculatory alterations and the no-reflow phenomenon in vivo after experimental pediatric cardiac arrest. J Cereb Blood Flow Metab, 271678X17744717, doi:10.1177/0271678X17744717 (2017).

13     Chakraborty, K., Raundhal, M., Chen, B. B., Morse, C., Tyurina, Y. Y., Khare, A., Oriss, T. B., Huff, R., Lee, J. S., St Croix, C. M., Watkins, S., Mallampalli, R. K., Kagan, V. E., Ray, A. & Ray, P. The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia. Nat Commun 8, 13944, doi:10.1038/ncomms13944 (2017).

14     Braganza, A., Li, J., Zeng, X., Yates, N. A., Dey, N. B., Andrews, J., Clark, J., Zamani, L., Wang, X. H., St Croix, C., O'Sullivan, R., Garcia-Exposito, L., Brodsky, J. L. & Sobol, R. W. UBE3B Is a Calmodulin-regulated, Mitochondrion-associated E3 Ubiquitin Ligase. J Biol Chem 292, 2470-2484, doi:10.1074/jbc.M116.766824 (2017).

15     Billaud, M., Phillippi, J. A., Kotlarczyk, M. P., Hill, J. C., Ellis, B. W., St Croix, C. M., Cantu-Medellin, N., Kelley, E. E. & Gleason, T. G. Elevated oxidative stress in the aortic media of patients with bicuspid aortic valve. J Thorac Cardiovasc Surg 154, 1756-1762, doi:10.1016/j.jtcvs.2017.05.065 (2017).

 

2016

16     Stoner, M. W., Thapa, D., Zhang, M., Gibson, G. A., Calderon, M. J., St Croix, C. M. & Scott, I. alpha-Lipoic acid promotes alpha-tubulin hyperacetylation and blocks the turnover of mitochondria through mitophagy. Biochem J 473, 1821-1830, doi:10.1042/BCJ20160281 (2016).

17     St Croix, C. M. & Steinhorn, R. H. New Thoughts about the Origin of Plexiform Lesions. Am J Respir Crit Care Med 193, 484-485, doi:10.1164/rccm.201510-1959ED (2016).

18     Pohl, P. H., Lozito, T. P., Cuperman, T., Yurube, T., Moon, H. J., Ngo, K., Tuan, R. S., St Croix, C., Sowa, G. A., Rodrigues, L. M., Kang, J. D. & Vo, N. V. Catabolic effects of endothelial cell-derived microparticles on disc cells: Implications in intervertebral disc neovascularization and degeneration. J Orthop Res 34, 1466-1474, doi:10.1002/jor.23298 (2016).

19     Olonisakin, T. F., Li, H., Xiong, Z., Kochman, E. J., Yu, M., Qu, Y., Hulver, M., Kolls, J. K., St Croix, C., Doi, Y., Nguyen, M. H., Shanks, R. M., Mallampalli, R. K., Kagan, V. E., Ray, A., Silverstein, R. L., Ray, P. & Lee, J. S. CD36 Provides Host Protection Against Klebsiella pneumoniae Intrapulmonary Infection by Enhancing Lipopolysaccharide Responsiveness and Macrophage Phagocytosis. J Infect Dis 214, 1865-1875, doi:10.1093/infdis/jiw451 (2016).

20     Mischler, S. E., Cauda, E. G., Di Giuseppe, M., McWilliams, L. J., St Croix, C., Sun, M., Franks, J. & Ortiz, L. A. Differential activation of RAW 264.7 macrophages by size-segregated crystalline silica. J Occup Med Toxicol 11, 57, doi:10.1186/s12995-016-0145-2 (2016).

21     Mao, G., Qu, F., St Croix, C. M., Tyurina, Y. Y., Planas-Iglesias, J., Jiang, J., Huang, Z., Amoscato, A. A., Tyurin, V. A., Kapralov, A. A., Cheikhi, A., Maguire, J., Klein-Seetharaman, J., Bayir, H. & Kagan, V. E. Mitochondrial Redox Opto-Lipidomics Reveals Mono-Oxygenated Cardiolipins as Pro-Apoptotic Death Signals. ACS Chem Biol 11, 530-540, doi:10.1021/acschembio.5b00737 (2016).

22     Lai, Y. C., Tabima, D. M., Dube, J. J., Hughan, K. S., Vanderpool, R. R., Goncharov, D. A., St Croix, C. M., Garcia-Ocana, A., Goncharova, E. A., Tofovic, S. P., Mora, A. L. & Gladwin, M. T. SIRT3-AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction. Circulation 133, 717-731, doi:10.1161/CIRCULATIONAHA.115.018935 (2016).

23     Khare, A., Raundhal, M., Chakraborty, K., Das, S., Corey, C., Kamga, C. K., Quesnelle, K., St Croix, C., Watkins, S. C., Morse, C., Oriss, T. B., Huff, R., Hannum, R., Ray, P., Shiva, S. & Ray, A. Mitochondrial H2O2 in Lung Antigen-Presenting Cells Blocks NF-kappaB Activation to Prevent Unwarranted Immune Activation. Cell Rep 15, 1700-1714, doi:10.1016/j.celrep.2016.04.060 (2016).

24     Kelly, N. J., Dandachi, N., Goncharov, D. A., Pena, A. Z., Radder, J. E., Gregory, A. D., Lai, Y. C., Leme, A. S., Gladwin, M. T., Goncharova, E. A., St Croix, C. M. & Shapiro, S. D. Automated Measurement of Blood Vessels in Tissues from Microscopy Images. Curr Protoc Cytom 78, 12 44 11-12 44 13, doi:10.1002/cpcy.10 (2016).

25     Kagan, V. E., Jiang, J., Huang, Z., Tyurina, Y. Y., Desbourdes, C., Cottet-Rousselle, C., Dar, H. H., Verma, M., Tyurin, V. A., Kapralov, A. A., Cheikhi, A., Mao, G., Stolz, D., St Croix, C. M., Watkins, S., Shen, Z., Li, Y., Greenberg, M. L., Tokarska-Schlattner, M., Boissan, M., Lacombe, M. L., Epand, R. M., Chu, C. T., Mallampalli, R. K., Bayir, H. & Schlattner, U. NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy. Cell Death Differ 23, 1140-1151, doi:10.1038/cdd.2015.160 (2016).

26     He, J., Wang, Y., Missinato, M. A., Onuoha, E., Perkins, L. A., Watkins, S. C., St Croix, C. M., Tsang, M. & Bruchez, M. P. A genetically targetable near-infrared photosensitizer. Nat Methods 13, 263-268, doi:10.1038/nmeth.3735 (2016).

27     Dezfulian, C., Kenny, E., Lamade, A., Misse, A., Krehel, N., St Croix, C., Kelley, E. E., Jackson, T. C., Uray, T., Rackley, J., Kochanek, P. M., Clark, R. S. & Bayir, H. Mechanistic characterization of nitrite-mediated neuroprotection after experimental cardiac arrest. J Neurochem 139, 419-431, doi:10.1111/jnc.13764 (2016).

 

2015

28     Zacherl, J. R., Tourkova, I., St Croix, C. M., Robinson, L. J., Peck Palmer, O. M., Mihalik, S. J. & Blair, H. C. Elaidate, an 18-carbon trans-monoenoic fatty acid, but not physiological fatty acids increases intracellular Zn(2+) in human macrophages. J Cell Biochem 116, 524-532, doi:10.1002/jcb.25002 (2015).

29     Wallace, C. T., St Croix, C. M. & Watkins, S. C. Data management and archiving in a large microscopy-and-imaging, multi-user facility: Problems and solutions. Mol Reprod Dev 82, 630-634, doi:10.1002/mrd.22538 (2015).

30     Phinney, D. G., Di Giuseppe, M., Njah, J., Sala, E., Shiva, S., St Croix, C. M., Stolz, D. B., Watkins, S. C., Di, Y. P., Leikauf, G. D., Kolls, J., Riches, D. W., Deiuliis, G., Kaminski, N., Boregowda, S. V., McKenna, D. H. & Ortiz, L. A. Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs. Nat Commun 6, 8472, doi:10.1038/ncomms9472 (2015).

31     Krawiec, J. T., Weinbaum, J. S., St Croix, C. M., Phillippi, J. A., Watkins, S. C., Rubin, J. P. & Vorp, D. A. A cautionary tale for autologous vascular tissue engineering: impact of human demographics on the ability of adipose-derived mesenchymal stem cells to recruit and differentiate into smooth muscle cells. Tissue Eng Part A 21, 426-437, doi:10.1089/ten.TEA.2014.0208 (2015).

32     Khoo, N. K., Cantu-Medellin, N., St Croix, C. & Kelley, E. E. In Vivo Immuno-Spin Trapping: Imaging the Footprints of Oxidative Stress. Curr Protoc Cytom 74, 12 42 11-11, doi:10.1002/0471142956.cy1242s74 (2015).

33     Ji, J., Baart, S., Vikulina, A. S., Clark, R. S., Anthonymuthu, T. S., Tyurin, V. A., Du, L., St Croix, C. M., Tyurina, Y. Y., Lewis, J., Skoda, E. M., Kline, A. E., Kochanek, P. M., Wipf, P., Kagan, V. E. & Bayir, H. Deciphering of mitochondrial cardiolipin oxidative signaling in cerebral ischemia-reperfusion. J Cereb Blood Flow Metab 35, 319-328, doi:10.1038/jcbfm.2014.204 (2015).

34     Balasubramanian, K., Maeda, A., Lee, J. S., Mohammadyani, D., Dar, H. H., Jiang, J. F., St Croix, C. M., Watkins, S., Tyurin, V. A., Tyurina, Y. Y., Kloditz, K., Polimova, A., Kapralova, V. I., Xiong, Z., Ray, P., Klein-Seetharaman, J., Mallampalli, R. K., Bayir, H., Fadeel, B. & Kagan, V. E. Dichotomous roles for externalized cardiolipin in extracellular signaling: Promotion of phagocytosis and attenuation of innate immunity. Sci Signal 8, ra95, doi:10.1126/scisignal.aaa6179 (2015).

 

2014

35     Yao, M., Rogers, N. M., Csanyi, G., Rodriguez, A. I., Ross, M. A., St Croix, C., Knupp, H., Novelli, E. M., Thomson, A. W., Pagano, P. J. & Isenberg, J. S. Thrombospondin-1 activation of signal-regulatory protein-alpha stimulates reactive oxygen species production and promotes renal ischemia reperfusion injury. J Am Soc Nephrol 25, 1171-1186, doi:10.1681/ASN.2013040433 (2014).

36     Sharifi-Sanjani, M., Shoushtari, A. H., Quiroz, M., Baust, J., Sestito, S. F., Mosher, M., Ross, M., McTiernan, C. F., St Croix, C. M., Bilonick, R. A., Champion, H. C. & Isenberg, J. S. Cardiac CD47 drives left ventricular heart failure through Ca2+-CaMKII-regulated induction of HDAC3. J Am Heart Assoc 3, e000670, doi:10.1161/JAHA.113.000670 (2014).

37     Kelley, E. E., Baust, J., Bonacci, G., Golin-Bisello, F., Devlin, J. E., St Croix, C. M., Watkins, S. C., Gor, S., Cantu-Medellin, N., Weidert, E. R., Frisbee, J. C., Gladwin, M. T., Champion, H. C., Freeman, B. A. & Khoo, N. K. Fatty acid nitroalkenes ameliorate glucose intolerance and pulmonary hypertension in high-fat diet-induced obesity. Cardiovasc Res 101, 352-363, doi:10.1093/cvr/cvt341 (2014).

38     Kamga Pride, C., Mo, L., Quesnelle, K., Dagda, R. K., Murillo, D., Geary, L., Corey, C., Portella, R., Zharikov, S., St Croix, C., Maniar, S., Chu, C. T., Khoo, N. K. & Shiva, S. Nitrite activates protein kinase A in normoxia to mediate mitochondrial fusion and tolerance to ischaemia/reperfusion. Cardiovasc Res 101, 57-68, doi:10.1093/cvr/cvt224 (2014).

39     Kagan, V. E., Kapralov, A. A., St Croix, C. M., Watkins, S. C., Kisin, E. R., Kotchey, G. P., Balasubramanian, K., Vlasova, II, Yu, J., Kim, K., Seo, W., Mallampalli, R. K., Star, A. & Shvedova, A. A. Lung macrophages "digest" carbon nanotubes using a superoxide/peroxynitrite oxidative pathway. ACS Nano 8, 5610-5621, doi:10.1021/nn406484b (2014).

40     Fazzi, F., Njah, J., Di Giuseppe, M., Winnica, D. E., Go, K., Sala, E., St Croix, C. M., Watkins, S. C., Tyurin, V. A., Phinney, D. G., Fattman, C. L., Leikauf, G. D., Kagan, V. E. & Ortiz, L. A. TNFR1/phox interaction and TNFR1 mitochondrial translocation Thwart silica-induced pulmonary fibrosis. J Immunol 192, 3837-3846, doi:10.4049/jimmunol.1103516 (2014).

41     Coblentz, J., St Croix, C. & Kiselyov, K. Loss of TRPML1 promotes production of reactive oxygen species: is oxidative damage a factor in mucolipidosis type IV? Biochem J 457, 361-368, doi:10.1042/BJ20130647 (2014).

 

Donna B. Stolz Ph.D.

2018

1       Yang, M. Q., Du, Q., Varley, P. R., Goswami, J., Liang, Z., Wang, R., Li, H., Stolz, D.  B. & Geller, D. A. Interferon regulatory factor 1 priming of tumour-derived exosomes enhances the antitumour immune response. Br J Cancer 118, 62-71, doi:10.1038/bjc.2017.389 (2018).

2       Yang, M. Q., Du, Q., Goswami, J., Varley, P. R., Chen, B., Wang, R. H., Morelli, A. E., Stolz, D.  B., Billiar, T. R., Li, J. & Geller, D. A. Interferon regulatory factor 1-Rab27a regulated extracellular vesicles promote liver ischemia/reperfusion injury. Hepatology 67, 1056-1070, doi:10.1002/hep.29605 (2018).

3       Xing, B., Brink, L. E., Maers, K., Sullivan, M. L., Bodnar, R. J., Stolz, D.  B. & Cambi, F. Conditional depletion of GSK3b protects oligodendrocytes from apoptosis and lessens demyelination in the acute cuprizone model. Glia, doi:10.1002/glia.23453 (2018).

4       Waltz, P. K., Kautza, B., Luciano, J., Dyer, M., Stolz, D.  B., Loughran, P., Neal, M. D., Sperry, J. L., Rosengart, M. R. & Zuckerbraun, B. S. Heme Oxygenase-2 Localizes to Mitochondria and Regulates Hypoxic Responses in Hepatocytes. Oxid Med Cell Longev 2018, 2021645, doi:10.1155/2018/2021645 (2018).

5       Saydmohammed, M., Yagi, H., Calderon, M., Clark, M. J., Feinstein, T., Sun, M., Stolz, D.  B., Watkins, S. C., Amack, J. D., Lo, C. W. & Tsang, M. Vertebrate myosin 1d regulates left-right organizer morphogenesis and laterality. Nat Commun 9, 3381, doi:10.1038/s41467-018-05866-2 (2018).

6       Sannino, S., Guerriero, C. J., Sabnis, A. J., Stolz, D.  B., Wallace, C. T., Wipf, P., Watkins, S. C., Bivona, T. G. & Brodsky, J. L. Compensatory increases of select proteostasis networks after Hsp70 inhibition in cancer cells. J Cell Sci 131, doi:10.1242/jcs.217760 (2018).

7       Robinson, A. R., Yousefzadeh, M. J., Rozgaja, T. A., Wang, J., Li, X., Tilstra, J. S., Feldman, C. H., Gregg, S. Q., Johnson, C. H., Skoda, E. M., Frantz, M. C., Bell-Temin, H., Pope-Varsalona, H., Gurkar, A. U., Nasto, L. A., Robinson, R. A. S., Fuhrmann-Stroissnigg, H., Czerwinska, J., McGowan, S. J., Cantu-Medellin, N., Harris, J. B., Maniar, S., Ross, M. A., Trussoni, C. E., LaRusso, N. F., Cifuentes-Pagano, E., Pagano, P. J., Tudek, B., Vo, N. V., Rigatti, L. H., Opresko, P. L., Stolz, D.  B., Watkins, S. C., Burd, C. E., Croix, C. M. S., Siuzdak, G., Yates, N. A., Robbins, P. D., Wang, Y., Wipf, P., Kelley, E. E. & Niedernhofer, L. J. Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging. Redox Biol 17, 259-273, doi:10.1016/j.redox.2018.04.007 (2018).

8       Pradhan-Sundd, T., Zhou, L., Vats, R., Jiang, A., Molina, L., Singh, S., Poddar, M., Russell, J., Stolz, D.  B., Oertel, M., Apte, U., Watkins, S., Ranganathan, S., Nejak-Bowen, K. N., Sundd, P. & Monga, S. P. Dual catenin loss in murine liver causes tight junctional deregulation and progressive intrahepatic cholestasis. Hepatology 67, 2320-2337, doi:10.1002/hep.29585 (2018).

9       Patel, A., Xue, Y., Hartley, R., Sant, V., Eles, J. R., Cui, X. T., Stolz, D.  B. & Sant, S. Hierarchically aligned fibrous hydrogel films through microfluidic self-assembly of graphene and polysaccharides. Biotechnol Bioeng, doi:10.1002/bit.26801 (2018).

10     Ono, Y., Perez-Gutierrez, A., Nakao, T., Dai, H., Camirand, G., Yoshida, O., Yokota, S., Stolz, D.  B., Ross, M. A., Morelli, A. E., Geller, D. A. & Thomson, A. W. Graft-infiltrating PD-L1(hi) cross-dressed dendritic cells regulate antidonor T cell responses in mouse liver transplant tolerance. Hepatology 67, 1499-1515, doi:10.1002/hep.29529 (2018).

11     Mukherjee, A., Hidvegi, T., Araya, P., Ewing, M., Stolz, D.  B. & Perlmutter, D. H. NFkappaB mitigates the pathological effects of misfolded alpha1-antitrypsin by activating autophagy and an integrated program of proteostasis mechanisms. Cell Death Differ, doi:10.1038/s41418-018-0130-7 (2018).

12     Liu, A., Li, S., Donnenberg, V., Fu, J., Gollin, S. M., Ma, H., Lu, C., Stolz, D.  B., Mapara, M. Y., Monaghan, S. A. & Lentzsch, S. Immunomodulatory drugs downregulate IKZF1 leading to expansion of hematopoietic progenitors with concomitant block of megakaryocytic maturation. Haematologica, doi:10.3324/haematol.2018.188227 (2018).

13     Guo, C., Zou, J., Wen, Y., Fang, W., Stolz, D.  B., Sun, M. & Wei, X. Apical Cell-Cell Adhesions Reconcile Symmetry and Asymmetry in Zebrafish Neurulation. iScience 3, 63-85, doi:10.1016/j.isci.2018.04.007 (2018).

14     Garbacz, W. G., Uppal, H., Yan, J., Xu, M., Ren, S., Stolz, D.  B., Huang, M. & Xie, W. Chronic Activation of Liver X Receptor Sensitizes Mice to High Cholesterol Diet-Induced Gut Toxicity. Mol Pharmacol 94, 1145-1154, doi:10.1124/mol.118.112672 (2018).

15     Clark, A. M., Kumar, M. P., Wheeler, S. E., Young, C. L., Venkataramanan, R., Stolz, D.  B., Griffith, L. G., Lauffenburger, D. A. & Wells, A. A Model of Dormant-Emergent Metastatic Breast Cancer Progression Enabling Exploration of Biomarker Signatures. Mol Cell Proteomics 17, 619-630, doi:10.1074/mcp.RA117.000370 (2018).

16     Chen, D., Tong, J., Yang, L., Wei, L., Stolz, D.  B., Yu, J., Zhang, J. & Zhang, L. PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors. Proc Natl Acad Sci U S A 115, 3930-3935, doi:10.1073/pnas.1717190115 (2018).

17     Boyd-Shiwarski, C. R., Shiwarski, D. J., Roy, A., Namboodiri, H. N., Nkashama, L. J., Xie, J., McClain, K. L., Marciszyn, A., Kleyman, T. R., Tan, R. J., Stolz, D.  B., Puthenveedu, M. A., Huang, C. L. & Subramanya, A. R. Potassium-regulated distal tubule WNK bodies are kidney-specific WNK1 dependent. Mol Biol Cell 29, 499-509, doi:10.1091/mbc.E17-08-0529 (2018).

18     Begum, G., Song, S., Wang, S., Zhao, H., Bhuiyan, M. I. H., Li, E., Nepomuceno, R., Ye, Q., Sun, M., Calderon, M. J., Stolz, D.  B., St Croix, C., Watkins, S. C., Chen, Y., He, P., Shull, G. E. & Sun, D. Selective knockout of astrocytic Na(+) /H(+) exchanger isoform 1 reduces astrogliosis, BBB damage, infarction, and improves neurological function after ischemic stroke. Glia 66, 126-144, doi:10.1002/glia.23232 (2018).

19     Beckwitt, C. H., Clark, A. M., Wheeler, S., Taylor, D. L., Stolz, D.  B., Griffith, L. & Wells, A. Liver 'organ on a chip'. Exp Cell Res 363, 15-25, doi:10.1016/j.yexcr.2017.12.023 (2018).

 

2017

20     Zhao, J., Fuhrmann-Stroissnigg, H., Gurkar, A. U., Flores, R. R., Dorronsoro, A., Stolz, D.  B., St Croix, C. M., Niedernhofer, L. J. & Robbins, P. D. Quantitative Analysis of Cellular Senescence in Culture and In Vivo. Curr Protoc Cytom 79, 9 51 51-59 51 25, doi:10.1002/cpcy.16 (2017).

21     Yates, C. C., Rodrigues, M., Nuschke, A., Johnson, Z. I., Whaley, D., Stolz, D. , Newsome, J. & Wells, A. Multipotent stromal cells/mesenchymal stem cells and fibroblasts combine to minimize skin hypertrophic scarring. Stem Cell Res Ther 8, 193, doi:10.1186/s13287-017-0644-9 (2017).

22     Uppala, R., Dudiak, B., Beck, M. E., Bharathi, S. S., Zhang, Y., Stolz, D.  B. & Goetzman, E. S. Aspirin increases mitochondrial fatty acid oxidation. Biochem Biophys Res Commun 482, 346-351, doi:10.1016/j.bbrc.2016.11.066 (2017).

23     Suofu, Y., Li, W., Jean-Alphonse, F. G., Jia, J., Khattar, N. K., Li, J., Baranov, S. V., Leronni, D., Mihalik, A. C., He, Y., Cecon, E., Wehbi, V. L., Kim, J., Heath, B. E., Baranova, O. V., Wang, X., Gable, M. J., Kretz, E. S., Di Benedetto, G., Lezon, T. R., Ferrando, L. M., Larkin, T. M., Sullivan, M., Yablonska, S., Wang, J., Minnigh, M. B., Guillaumet, G., Suzenet, F., Richardson, R. M., Poloyac, S. M., Stolz, D.  B., Jockers, R., Witt-Enderby, P. A., Carlisle, D. L., Vilardaga, J. P. & Friedlander, R. M. Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release. Proc Natl Acad Sci U S A 114, E7997-E8006, doi:10.1073/pnas.1705768114 (2017).

24     Soltys, K. A., Setoyama, K., Tafaleng, E. N., Soto Gutierrez, A., Fong, J., Fukumitsu, K., Nishikawa, T., Nagaya, M., Sada, R., Haberman, K., Gramignoli, R., Dorko, K., Tahan, V., Dreyzin, A., Baskin, K., Crowley, J. J., Quader, M. A., Deutsch, M., Ashokkumar, C., Shneider, B. L., Squires, R. H., Ranganathan, S., Reyes-Mugica, M., Dobrowolski, S. F., Mazariegos, G., Elango, R., Stolz, D.  B., Strom, S. C., Vockley, G., Roy-Chowdhury, J., Cascalho, M., Guha, C., Sindhi, R., Platt, J. L. & Fox, I. J. Host conditioning and rejection monitoring in hepatocyte transplantation in humans. J Hepatol 66, 987-1000, doi:10.1016/j.jhep.2016.12.017 (2017).

25     Schmitt, D. M., Barnes, R., Rogerson, T., Haught, A., Mazzella, L. K., Ford, M., Gilson, T., Birch, J. W., Sjostedt, A., Reed, D. S., Franks, J. M., Stolz, D.  B., Denvir, J., Fan, J., Rekulapally, S., Primerano, D. A. & Horzempa, J. The Role and Mechanism of Erythrocyte Invasion by Francisella tularensis. Front Cell Infect Microbiol 7, 173, doi:10.3389/fcimb.2017.00173 (2017).

26     Lothet, E. H., Shaw, K. M., Lu, H., Zhuo, J., Wang, Y. T., Gu, S., Stolz, D.  B., Jansen, E. D., Horn, C. C., Chiel, H. J. & Jenkins, M. W. Selective inhibition of small-diameter axons using infrared light. Sci Rep 7, 3275, doi:10.1038/s41598-017-03374-9 (2017).

27     Li, G., Larregina, A. T., Domsic, R. T., Stolz, D.  B., Medsger, T. A., Jr., Lafyatis, R. & Fuschiotti, P. Skin-Resident Effector Memory CD8(+)CD28(-) T Cells Exhibit a Profibrotic Phenotype in Patients with Systemic Sclerosis. J Invest Dermatol 137, 1042-1050, doi:10.1016/j.jid.2016.11.037 (2017).

28     Khan, Z., Venkat, V. L., Soltys, K. A., Stolz, D.  B. & Ranganathan, S. A Challenging Case of Severe Infantile Cholestasis in Alpha-1 Antitrypsin Deficiency. Pediatr Dev Pathol 20, 176-181, doi:10.1177/1093526616686259 (2017).

29     Kader, M., Alaoui-El-Azher, M., Vorhauer, J., Kode, B. B., Wells, J. Z., Stolz, D. , Michalopoulos, G., Wells, A., Scott, M. & Ismail, N. MyD88-dependent inflammasome activation and autophagy inhibition contributes to Ehrlichia-induced liver injury and toxic shock. PLoS Pathog 13, e1006644, doi:10.1371/journal.ppat.1006644 (2017).

30     Fu, H., Tian, Y., Zhou, L., Zhou, D., Tan, R. J., Stolz, D.  B. & Liu, Y. Tenascin-C Is a Major Component of the Fibrogenic Niche in Kidney Fibrosis. J Am Soc Nephrol 28, 785-801, doi:10.1681/ASN.2016020165 (2017).

31     Franks, J., Wallace, C. T., Shibata, M., Suga, M., Erdman, N., Stolz, D.  B. & Watkins, S. C. Correlative Fluorescence and Electron Microscopy in 3D-Scanning Electron Microscope Perspective. Curr Protoc Cytom 80, 12 45 11-12 45 15, doi:10.1002/cpcy.18 (2017).

32     Efimova, N., Korobova, F., Stankewich, M. C., Moberly, A. H., Stolz, D.  B., Wang, J., Kashina, A., Ma, M. & Svitkina, T. betaIII Spectrin Is Necessary for Formation of the Constricted Neck of Dendritic Spines and Regulation of Synaptic Activity in Neurons. J Neurosci 37, 6442-6459, doi:10.1523/JNEUROSCI.3520-16.2017 (2017).

33     Buijs, N., Oosterink, J. E., Jessup, M., Schierbeek, H., Stolz, D.  B., Houdijk, A. P., Geller, D. A. & van Leeuwen, P. A. A new key player in VEGF-dependent angiogenesis in human hepatocellular carcinoma: dimethylarginine dimethylaminohydrolase 1. Angiogenesis 20, 557-565, doi:10.1007/s10456-017-9567-4 (2017).

 

2016

34     Zhang, C., Ferrari, R., Beezhold, K., Stearns-Reider, K., D'Amore, A., Haschak, M., Stolz, D. , Robbins, P. D., Barchowsky, A. & Ambrosio, F. Arsenic Promotes NF-Kappab-Mediated Fibroblast Dysfunction and Matrix Remodeling to Impair Muscle Stem Cell Function. Stem Cells 34, 732-742, doi:10.1002/stem.2232 (2016).

35     Xiao, X., Jones, G., Sevilla, W. A., Stolz, D.  B., Magee, K. E., Haughney, M., Mukherjee, A., Wang, Y. & Lowe, M. E. A Carboxyl Ester Lipase (CEL) Mutant Causes Chronic Pancreatitis by Forming Intracellular Aggregates That Activate Apoptosis. J Biol Chem 291, 23224-23236, doi:10.1074/jbc.M116.734384 (2016).

36     Wickline, E. D., Dale, I. W., Merkel, C. D., Heier, J. A., Stolz, D.  B. & Kwiatkowski, A. V. alphaT-Catenin Is a Constitutive Actin-binding alpha-Catenin That Directly Couples the Cadherin.Catenin Complex to Actin Filaments. J Biol Chem 291, 15687-15699, doi:10.1074/jbc.M116.735423 (2016).

37     Treat, A. C., Wheeler, D. S., Stolz, D.  B., Tsang, M., Friedman, P. A. & Romero, G. The PDZ Protein Na+/H+ Exchanger Regulatory Factor-1 (NHERF1) Regulates Planar Cell Polarity and Motile Cilia Organization. PLoS One 11, e0153144, doi:10.1371/journal.pone.0153144 (2016).

38     Sankapal, S., Gupta, P., Ratner, D., Ding, M., Shen, C., Sanyal, A., Stolz, D. , Cu-Uvin, S., Ramratnam, B. & Chen, Y. HIV Exposure to the Epithelia in Ectocervical and Colon Tissues Induces Inflammatory Cytokines Without Tight Junction Disruption. AIDS Res Hum Retroviruses 32, 1054-1066, doi:10.1089/AID.2015.0185 (2016).

39     Patel, A., Xue, Y., Mukundan, S., Rohan, L. C., Sant, V., Stolz, D.  B. & Sant, S. Cell-Instructive Graphene-Containing Nanocomposites Induce Multinucleated Myotube Formation. Ann Biomed Eng 44, 2036-2048, doi:10.1007/s10439-016-1586-6 (2016).

40     Nuschke, A., Rodrigues, M., Rivera, J., Yates, C., Whaley, D., Stolz, D. , Griffith, L. & Wells, A. Epidermal Growth Factor Tethered to beta-Tricalcium Phosphate Bone Scaffolds via a High-Affinity Binding Peptide Enhances Survival of Human Mesenchymal Stem Cells/Multipotent Stromal Cells in an Immune-Competent Parafascial Implantation Assay in Mice. Stem Cells Transl Med 5, 1580-1586, doi:10.5966/sctm.2015-0326 (2016).

41     Long, T. J., Cosgrove, P. A., Dunn, R. T., 2nd, Stolz, D.  B., Hamadeh, H., Afshari, C., McBride, H. & Griffith, L. G. Modeling Therapeutic Antibody-Small Molecule Drug-Drug Interactions Using a Three-Dimensional Perfusable Human Liver Coculture Platform. Drug Metab Dispos 44, 1940-1948, doi:10.1124/dmd.116.071456 (2016).

42     Li, H. S., Stolz, D.  B. & Romero, G. Characterization of Endocytic Vesicles Using Magnetic Microbeads Coated with Signaling Ligands. Traffic 17, 1150, doi:10.1111/tra.12424 (2016).

43     Kostereva, N. V., Wang, Y., Fletcher, D. R., Unadkat, J. V., Schnider, J. T., Komatsu, C., Yang, Y., Stolz, D.  B., Davis, M. R., Plock, J. A. & Gorantla, V. S. IGF-1 and Chondroitinase ABC Augment Nerve Regeneration after Vascularized Composite Limb Allotransplantation. PLoS One 11, e0156149, doi:10.1371/journal.pone.0156149 (2016).

44     Kimura, S., Ozaki, K. S., Ueki, S., Zhang, M., Yokota, S., Stolz, D.  B., Geller, D. A. & Murase, N. Contribution of alloantigens to hepatic ischemia/reperfusion injury: Roles of natural killer cells and innate immune recognition of nonself. Liver Transpl 22, 80-90, doi:10.1002/lt.24330 (2016).

45     Khan, Z., Venkat, V. L., Soltys, K. A., Stolz, D.  B. & Ranganathan, S. A Challenging Case of Severe Infantile Cholestasis in Alpha-1 Antitrypsin Deficiency. Pediatr Dev Pathol, doi:10.2350/15-09-1711-CR.1 (2016).

46     Kagan, V. E., Jiang, J., Huang, Z., Tyurina, Y. Y., Desbourdes, C., Cottet-Rousselle, C., Dar, H. H., Verma, M., Tyurin, V. A., Kapralov, A. A., Cheikhi, A., Mao, G., Stolz, D. , St Croix, C. M., Watkins, S., Shen, Z., Li, Y., Greenberg, M. L., Tokarska-Schlattner, M., Boissan, M., Lacombe, M. L., Epand, R. M., Chu, C. T., Mallampalli, R. K., Bayir, H. & Schlattner, U. NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy. Cell Death Differ 23, 1140-1151, doi:10.1038/cdd.2015.160 (2016).

47     Huleihel, L., Hussey, G. S., Naranjo, J. D., Zhang, L., Dziki, J. L., Turner, N. J., Stolz, D.  B. & Badylak, S. F. Matrix-bound nanovesicles within ECM bioscaffolds. Sci Adv 2, e1600502, doi:10.1126/sciadv.1600502 (2016).

48     Demetris, A. J., Bellamy, C. O., Gandhi, C. R., Prost, S., Nakanuma, Y. & Stolz, D.  B. Functional Immune Anatomy of the Liver-As an Allograft. Am J Transplant 16, 1653-1680, doi:10.1111/ajt.13749 (2016).

49     Dangi, A., Huang, C., Tandon, A., Stolz, D. , Wu, T. & Gandhi, C. R. Endotoxin-stimulated Rat Hepatic Stellate Cells Induce Autophagy in Hepatocytes as a Survival Mechanism. J Cell Physiol 231, 94-105, doi:10.1002/jcp.25055 (2016).

50     Cunningham, K. E., Vincent, G., Sodhi, C. P., Novak, E. A., Ranganathan, S., Egan, C. E., Stolz, D.  B., Rogers, M. B., Firek, B., Morowitz, M. J., Gittes, G. K., Zuckerbraun, B. S., Hackam, D. J. & Mollen, K. P. Peroxisome Proliferator-activated Receptor-gamma Coactivator 1-alpha (PGC1alpha) Protects against Experimental Murine Colitis. J Biol Chem 291, 10184-10200, doi:10.1074/jbc.M115.688812 (2016).

51     Corti, P., Xue, J., Tejero, J., Wajih, N., Sun, M., Stolz, D.  B., Tsang, M., Kim-Shapiro, D. B. & Gladwin, M. T. Globin X is a six-coordinate globin that reduces nitrite to nitric oxide in fish red blood cells. Proc Natl Acad Sci U S A 113, 8538-8543, doi:10.1073/pnas.1522670113 (2016).

52     Clark, A. M., Wheeler, S. E., Young, C. L., Stockdale, L., Shepard Neiman, J., Zhao, W., Stolz, D.  B., Venkataramanan, R., Lauffenburger, D., Griffith, L. & Wells, A. A liver microphysiological system of tumor cell dormancy and inflammatory responsiveness is affected by scaffold properties. Lab Chip 17, 156-168, doi:10.1039/c6lc01171c (2016).

53     Casinelli, G., LaRosa, J., Sharma, M., Cherok, E., Banerjee, S., Branca, M., Edmunds, L., Wang, Y., Sims-Lucas, S., Churley, L., Kelly, S., Sun, M., Stolz, D.  & Graves, J. A. N-Myc overexpression increases cisplatin resistance in neuroblastoma via deregulation of mitochondrial dynamics. Cell Death Discov 2, 16082, doi:10.1038/cddiscovery.2016.82 (2016).

 

2015

54     Zhou, L., Pradhan-Sundd, T., Poddar, M., Singh, S., Kikuchi, A., Stolz, D.  B., Shou, W., Li, Z., Nejak-Bowen, K. N. & Monga, S. P. Mice with Hepatic Loss of the Desmosomal Protein gamma-Catenin Are Prone to Cholestatic Injury and Chemical Carcinogenesis. Am J Pathol 185, 3274-3289, doi:10.1016/j.ajpath.2015.08.019 (2015).

55     Zhao, Y., Olonisakin, T. F., Xiong, Z., Hulver, M., Sayeed, S., Yu, M. T., Gregory, A. D., Kochman, E. J., Chen, B. B., Mallampalli, R. K., Sun, M., Silverstein, R. L., Stolz, D.  B., Shapiro, S. D., Ray, A., Ray, P. & Lee, J. S. Thrombospondin-1 restrains neutrophil granule serine protease function and regulates the innate immune response during Klebsiella pneumoniae infection. Mucosal Immunol 8, 896-905, doi:10.1038/mi.2014.120 (2015).

56     Yokota, S., Yoshida, O., Dou, L., Spadaro, A. V., Isse, K., Ross, M. A., Stolz, D.  B., Kimura, S., Du, Q., Demetris, A. J., Thomson, A. W. & Geller, D. A. IRF-1 promotes liver transplant ischemia/reperfusion injury via hepatocyte IL-15/IL-15Ralpha production. J Immunol 194, 6045-6056, doi:10.4049/jimmunol.1402505 (2015).

57     Wheeler, D. S., Underhill, S. M., Stolz, D.  B., Murdoch, G. H., Thiels, E., Romero, G. & Amara, S. G. Amphetamine activates Rho GTPase signaling to mediate dopamine transporter internalization and acute behavioral effects of amphetamine. Proc Natl Acad Sci U S A 112, E7138-7147, doi:10.1073/pnas.1511670112 (2015).

58     Tafaleng, E. N., Chakraborty, S., Han, B., Hale, P., Wu, W., Soto-Gutierrez, A., Feghali-Bostwick, C. A., Wilson, A. A., Kotton, D. N., Nagaya, M., Strom, S. C., Roy-Chowdhury, J., Stolz, D.  B., Perlmutter, D. H. & Fox, I. J. Induced pluripotent stem cells model personalized variations in liver disease resulting from alpha1-antitrypsin deficiency. Hepatology 62, 147-157, doi:10.1002/hep.27753 (2015).

59     Stolz, D.  B. & Sims-Lucas, S. Unwrapping the origins and roles of the renal endothelium. Pediatr Nephrol 30, 865-872, doi:10.1007/s00467-014-2798-3 (2015).

60     Schoiswohl, G., Stefanovic-Racic, M., Menke, M. N., Wills, R. C., Surlow, B. A., Basantani, M. K., Sitnick, M. T., Cai, L., Yazbeck, C. F., Stolz, D.  B., Pulinilkunnil, T., O'Doherty, R. M. & Kershaw, E. E. Impact of Reduced ATGL-Mediated Adipocyte Lipolysis on Obesity-Associated Insulin Resistance and Inflammation in Male Mice. Endocrinology 156, 3610-3624, doi:10.1210/en.2015-1322 (2015).

61     Reay, D. P., Bastacky, S. I., Wack, K. E., Stolz, D.  B., Robbins, P. D. & Clemens, P. R. D-Amino Acid Substitution of Peptide-Mediated NF-kappaB Suppression in mdx Mice Preserves Therapeutic Benefit in Skeletal Muscle, but Causes Kidney Toxicity. Mol Med 21, 442-452, doi:10.2119/molmed.2013.00141 (2015).

62     Phinney, D. G., Di Giuseppe, M., Njah, J., Sala, E., Shiva, S., St Croix, C. M., Stolz, D.  B., Watkins, S. C., Di, Y. P., Leikauf, G. D., Kolls, J., Riches, D. W., Deiuliis, G., Kaminski, N., Boregowda, S. V., McKenna, D. H. & Ortiz, L. A. Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs. Nat Commun 6, 8472, doi:10.1038/ncomms9472 (2015).

63     Manohar, R., Li, Y., Fohrer, H., Guzik, L., Stolz, D.  B., Chandran, U. R., LaFramboise, W. A. & Lagasse, E. Identification of a candidate stem cell in human gallbladder. Stem Cell Res 14, 258-269, doi:10.1016/j.scr.2014.12.003 (2015).

64     I, O. S., Zhang, W., Wasserman, D. H., Liew, C. W., Liu, J., Paik, J., DePinho, R. A., Stolz, D.  B., Kahn, C. R., Schwartz, M. W. & Unterman, T. G. FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization. Nat Commun 6, 7079, doi:10.1038/ncomms8079 (2015).

65     Himes, K. P., Young, A., Koppes, E., Stolz, D. , Barak, Y., Sadovsky, Y. & Chaillet, J. R. Loss of inherited genomic imprints in mice leads to severe disruption in placental lipid metabolism. Placenta 36, 389-396, doi:10.1016/j.placenta.2015.01.012 (2015).

66     Hidvegi, T., Stolz, D.  B., Alcorn, J. F., Yousem, S. A., Wang, J., Leme, A. S., Houghton, A. M., Hale, P., Ewing, M., Cai, H., Garchar, E. A., Pastore, N., Annunziata, P., Kaminski, N., Pilewski, J., Shapiro, S. D., Pak, S. C., Silverman, G. A., Brunetti-Pierri, N. & Perlmutter, D. H. Enhancing Autophagy with Drugs or Lung-directed Gene Therapy Reverses the Pathological Effects of Respiratory Epithelial Cell Proteinopathy. J Biol Chem 290, 29742-29757, doi:10.1074/jbc.M115.691253 (2015).

67     Harris, K. G., Morosky, S. A., Drummond, C. G., Patel, M., Kim, C., Stolz, D.  B., Bergelson, J. M., Cherry, S. & Coyne, C. B. RIP3 Regulates Autophagy and Promotes Coxsackievirus B3 Infection of Intestinal Epithelial Cells. Cell Host Microbe 18, 221-232, doi:10.1016/j.chom.2015.07.007 (2015).

68     Geskin, L. J., Viragova, S., Stolz, D.  B. & Fuschiotti, P. Interleukin-13 is overexpressed in cutaneous T-cell lymphoma cells and regulates their proliferation. Blood 125, 2798-2805, doi:10.1182/blood-2014-07-590398 (2015).

69     Gandhi, C. R., Chaillet, J. R., Nalesnik, M. A., Kumar, S., Dangi, A., Demetris, A. J., Ferrell, R., Wu, T., Divanovic, S., Stankeiwicz, T., Shaffer, B., Stolz, D.  B., Harvey, S. A., Wang, J. & Starzl, T. E. Liver-specific deletion of augmenter of liver regeneration accelerates development of steatohepatitis and hepatocellular carcinoma in mice. Gastroenterology 148, 379-391 e374, doi:10.1053/j.gastro.2014.10.008 (2015).

70     Dheer, R., Patterson, J., Dudash, M., Stachler, E. N., Bibby, K. J., Stolz, D.  B., Shiva, S., Wang, Z., Hazen, S. L., Barchowsky, A. & Stolz, J. F. Arsenic induces structural and compositional colonic microbiome change and promotes host nitrogen and amino acid metabolism. Toxicol Appl Pharmacol 289, 397-408, doi:10.1016/j.taap.2015.10.020 (2015).

 

2014

71     Zhao, Y., Xiong, Z., Lechner, E. J., Klenotic, P. A., Hamburg, B. J., Hulver, M., Khare, A., Oriss, T., Mangalmurti, N., Chan, Y., Zhang, Y., Ross, M. A., Stolz, D.  B., Rosengart, M. R., Pilewski, J., Ray, P., Ray, A., Silverstein, R. L. & Lee, J. S. Thrombospondin-1 triggers macrophage IL-10 production and promotes resolution of experimental lung injury. Mucosal Immunol 7, 440-448, doi:10.1038/mi.2013.63 (2014).

72     Zhang, Y., Ghazwani, M., Li, J., Sun, M., Stolz, D.  B., He, F., Fan, J., Xie, W. & Li, S. MiR-29b inhibits collagen maturation in hepatic stellate cells through down-regulating the expression of HSP47 and lysyl oxidase. Biochem Biophys Res Commun 446, 940-944, doi:10.1016/j.bbrc.2014.03.037 (2014).

73     Zhang, L., Franks, J., Stolz, D.  B., Conway, J. F. & Thibodeau, P. H. Inducible polymerization and two-dimensional assembly of the repeats-in-toxin (RTX) domain from the Pseudomonas aeruginosa alkaline protease. Biochemistry 53, 6452-6462, doi:10.1021/bi5007546 (2014).

74     Yun, H., Lathrop, K. L., Yang, E., Sun, M., Kagemann, L., Fu, V., Stolz, D.  B., Schuman, J. S. & Du, Y. A laser-induced mouse model with long-term intraocular pressure elevation. PLoS One 9, e107446, doi:10.1371/journal.pone.0107446 (2014).

75     Wheeler, S. E., Clark, A. M., Taylor, D. P., Young, C. L., Pillai, V. C., Stolz, D.  B., Venkataramanan, R., Lauffenburger, D., Griffith, L. & Wells, A. Spontaneous dormancy of metastatic breast cancer cells in an all human liver microphysiologic system. Br J Cancer 111, 2342-2350, doi:10.1038/bjc.2014.533 (2014).

76     Tanaka, Y., Shigemura, N., Noda, K., Kawamura, T., Isse, K., Stolz, D.  B. & Bermudez, C. A. Optimal lung inflation techniques in a rat lung transplantation model: a revisit. Thorac Cardiovasc Surg 62, 427-433, doi:10.1055/s-0034-1373902 (2014).

77     Stewart, R. K., Dangi, A., Huang, C., Murase, N., Kimura, S., Stolz, D.  B., Wilson, G. C., Lentsch, A. B. & Gandhi, C. R. A novel mouse model of depletion of stellate cells clarifies their role in ischemia/reperfusion- and endotoxin-induced acute liver injury. J Hepatol 60, 298-305, doi:10.1016/j.jhep.2013.09.013 (2014).

78     Qian, W., Wang, J., Roginskaya, V., McDermott, L. A., Edwards, R. P., Stolz, D.  B., Llambi, F., Green, D. R. & Van Houten, B. Novel combination of mitochondrial division inhibitor 1 (mdivi-1) and platinum agents produces synergistic pro-apoptotic effect in drug resistant tumor cells. Oncotarget 5, 4180-4194, doi:10.18632/oncotarget.1944 (2014).

79     Norris, C. A., He, M., Kang, L. I., Ding, M. Q., Radder, J. E., Haynes, M. M., Yang, Y., Paranjpe, S., Bowen, W. C., Orr, A., Michalopoulos, G. K., Stolz, D.  B. & Mars, W. M. Synthesis of IL-6 by hepatocytes is a normal response to common hepatic stimuli. PLoS One 9, e96053, doi:10.1371/journal.pone.0096053 (2014).

80     Muller, L., Hong, C. S., Stolz, D.  B., Watkins, S. C. & Whiteside, T. L. Isolation of biologically-active exosomes from human plasma. J Immunol Methods 411, 55-65, doi:10.1016/j.jim.2014.06.007 (2014).

81     Marrone, A. K., Stolz, D.  B., Bastacky, S. I., Kostka, D., Bodnar, A. J. & Ho, J. MicroRNA-17~92 is required for nephrogenesis and renal function. J Am Soc Nephrol 25, 1440-1452, doi:10.1681/ASN.2013040390 (2014).

82     Long, O. S., Benson, J. A., Kwak, J. H., Luke, C. J., Gosai, S. J., O'Reilly, L. P., Wang, Y., Li, J., Vetica, A. C., Miedel, M. T., Stolz, D.  B., Watkins, S. C., Zuchner, S., Perlmutter, D. H., Silverman, G. A. & Pak, S. C. A C. elegans model of human alpha1-antitrypsin deficiency links components of the RNAi pathway to misfolded protein turnover. Hum Mol Genet 23, 5109-5122, doi:10.1093/hmg/ddu235 (2014).

83     Lee, S., Yamada, T., Osako, T., Stolz, D.  B., Abe, M., McCurry, K. R., Murase, N., Kotani, J. & Nakao, A. Recipient hyperbilirubinaemia protects cardiac graft in rat heterotopic heart transplantation. Eur J Cardiothorac Surg 45, 481-488, doi:10.1093/ejcts/ezt402 (2014).

84     Delorme-Axford, E., Morosky, S., Bomberger, J., Stolz, D.  B., Jackson, W. T. & Coyne, C. B. BPIFB3 regulates autophagy and coxsackievirus B replication through a noncanonical pathway independent of the core initiation machinery. MBio 5, e02147, doi:10.1128/mBio.02147-14 (2014).

85     Clark, A. M., Wheeler, S. E., Taylor, D. P., Pillai, V. C., Young, C. L., Prantil-Baun, R., Nguyen, T., Stolz, D.  B., Borenstein, J. T., Lauffenburger, D. A., Venkataramanan, R., Griffith, L. G. & Wells, A. A microphysiological system model of therapy for liver micrometastases. Exp Biol Med (Maywood) 239, 1170-1179, doi:10.1177/1535370214532596 (2014).

86     Bowen, W. C., Michalopoulos, A. W., Orr, A., Ding, M. Q., Stolz, D.  B. & Michalopoulos, G. K. Development of a chemically defined medium and discovery of new mitogenic growth factors for mouse hepatocytes: mitogenic effects of FGF1/2 and PDGF. PLoS One 9, e95487, doi:10.1371/journal.pone.0095487 (2014).

87     Avin, K. G., Coen, P. M., Huang, W., Stolz, D.  B., Sowa, G. A., Dube, J. J., Goodpaster, B. H., O'Doherty, R. M. & Ambrosio, F. Skeletal muscle as a regulator of the longevity protein, Klotho. Front Physiol 5, 189, doi:10.3389/fphys.2014.00189 (2014).

88     Ambrosio, F., Brown, E., Stolz, D. , Ferrari, R., Goodpaster, B., Deasy, B., Distefano, G., Roperti, A., Cheikhi, A., Garciafigueroa, Y. & Barchowsky, A. Arsenic induces sustained impairment of skeletal muscle and muscle progenitor cell ultrastructure and bioenergetics. Free Radic Biol Med 74, 64-73, doi:10.1016/j.freeradbiomed.2014.06.012 (2014).

89     Allen, R. A., Wu, W., Yao, M., Dutta, D., Duan, X., Bachman, T. N., Champion, H. C., Stolz, D.  B., Robertson, A. M., Kim, K., Isenberg, J. S. & Wang, Y. Nerve regeneration and elastin formation within poly(glycerol sebacate)-based synthetic arterial grafts one-year post-implantation in a rat model. Biomaterials 35, 165-173, doi:10.1016/j.biomaterials.2013.09.081 (2014).

 

Alan M. Watson Ph.D.

2018

1       Waxman, S., Loewen, R. T., Dang, Y., Watkins, S. C., Watson, A. M. & Loewen, N. A. High-Resolution, Three-Dimensional Reconstruction of the Outflow Tract Demonstrates Segmental Differences in Cleared Eyes. Invest Ophthalmol Vis Sci 59, 2371-2380, doi:10.1167/iovs.17-23075 (2018).

2       Sanders, S. M., Ma, Z., Hughes, J. M., Riscoe, B. M., Gibson, G. A., Watson, A. M., Flici, H., Frank, U., Schnitzler, C. E., Baxevanis, A. D. & Nicotra, M. L. CRISPR/Cas9-mediated gene knockin in the hydroid Hydractinia symbiolongicarpus. BMC Genomics 19, 649, doi:10.1186/s12864-018-5032-z (2018).

3.      Sean, D., Czech, J.,  Ropelewski, A., Wetzel, A. W., Hood, G., Simmel, Derek., Bruchez, Marcel., Watkins, S. C., & Watson, A. M. “Applying IRODS to the Brain Image Library.” In Proceedings of the Practice and Experience on Advanced Research Computing, 79:1–79:4. PEARC ’18. New York, NY, USA: ACM, 2018. https://doi.org/10.1145/3219104.3229266.

4       Muntifering, M., Castranova, D., Gibson, G. A., Meyer, E., Kofron, M. & Watson, A. M. Clearing for Deep Tissue Imaging. Curr Protoc Cytom, e38, doi:10.1002/cpcy.38 (2018).

5       Lane, W. C., Dunn, M. D., Gardner, C. L., Lam, L. K. M., Watson, A. M., Hartman, A. L., Ryman, K. D. & Klimstra, W. B. The Efficacy of the Interferon Alpha/Beta Response versus Arboviruses Is Temperature Dependent. MBio 9, doi:10.1128/mBio.00535-18 (2018).

6       Lam, L. K. M., Watson, A. M., Ryman, K. D. & Klimstra, W. B. Gamma-interferon exerts a critical early restriction on replication and dissemination of yellow fever virus vaccine strain 17D-204. NPJ Vaccines 3, 5, doi:10.1038/s41541-017-0039-z (2018).

2017

7       Watson, A. M., Rose, A. H., Gibson, G. A., Gardner, C. L., Sun, C., Reed, D. S., Lam, L. K. M., St Croix, C. M., Strick, P. L., Klimstra, W. B. & Watkins, S. C. Ribbon scanning confocal for high-speed high-resolution volume imaging of brain. PLoS One 12, e0180486, doi:10.1371/journal.pone.0180486 (2017).

8       Watson, A. M. & Klimstra, W. B. T Cell-Mediated Immunity towards Yellow Fever Virus and Useful Animal Models. Viruses 9, doi:10.3390/v9040077 (2017).

2016

9       Watson, A. M., Lam, L. K., Klimstra, W. B. & Ryman, K. D. The 17D-204 Vaccine Strain-Induced Protection against Virulent Yellow Fever Virus Is Mediated by Humoral Immunity and CD4+ but not CD8+ T Cells. PLoS Pathog 12, e1005786, doi:10.1371/journal.ppat.1005786 (2016).

10     Troupin, A., Shirley, D., Londono-Renteria, B., Watson, A. M., McHale, C., Hall, A., Hartstone-Rose, A., Klimstra, W. B., Gomez, G. & Colpitts, T. M. A Role for Human Skin Mast Cells in Dengue Virus Infection and Systemic Spread. J Immunol 197, 4382-4391, doi:10.4049/jimmunol.1600846 (2016).

11     Tree, M. O., McKellar, D. R., Kieft, K. J., Watson, A. M., Ryman, K. D. & Conway, M. J. Insect-specific flavivirus infection is restricted by innate immunity in the vertebrate host. Virology 497, 81-91, doi:10.1016/j.virol.2016.07.005 (2016).

12     Conway, M. J., Londono-Renteria, B., Troupin, A., Watson, A. M., Klimstra, W. B., Fikrig, E. & Colpitts, T. M. Aedes aegypti D7 Saliva Protein Inhibits Dengue Virus Infection. PLoS Negl Trop Dis 10, e0004941, doi:10.1371/journal.pntd.0004941 (2016).

 

2014

13     Sun, C., Gardner, C. L., Watson, A. M., Ryman, K. D. & Klimstra, W. B. Stable, high-level expression of reporter proteins from improved alphavirus expression vectors to track replication and dissemination during encephalitic and arthritogenic disease. J Virol 88, 2035-2046, doi:10.1128/JVI.02990-13 (2014).