Winners Gallery

NK Cell with Tumor Cell

NK Cell with Tumor Cell

Here is shown an NK cell interacting with a tumor cell, starting the careful choreography of defining who will live and who will die, and what needs to be done to restore homeostasis in the response to tissue injury or damage. False color scanning electron micrograph.

- Donna Beer Stolz, PhD

Anaphase of MDA-MB-231 Cancer Cell

Anaphase of MDA-MB-231 Cancer Cell

Anaphase MDA-MB-231 breast cancer cell that is deficient in fission protein Drp1. Cells were stained with tubulin (red), mitochondria (green) and DNA (blue).

- Wei Qian, PhD

Ductal Carcinoma in Situ

Ductal Carcinoma in Situ

Ductal Carcinoma in situ (DCIS) cells cultured from surgical breast samples. Immunocytochemistry of luminal and basal epithelium . Epifluorescence microscopy, magnification: 4X objective

- Daniel Brown, PhD

Oncolytic Vaccinia Replication

Oncolytic Vaccinia Replication

Oncolytic vaccinia replication in MDA-MB-231 human breast cancer cell. 1200X original magnification, Confocal reconstruction of immune-labeled cell.

- Steve Thorne, PhD

The Beauty of a Beast

The Beauty of a Beast

Confocal micrograph of MDA breast cancer cells lentivirally transduced to express GFP-tubulin (green). Cells are stained for F-actin (red) and nuclei (blue). The large cell in the center clearly has trouble finishing the anaphase of the mitotic process, as it is multi-nucleated and have several MTOCs (microtubule organizing centers). A normal-sized “showoff” of an MDA cell to the lower left demonstrates how this part of the anaphase is really done!

- Per Basse, MD, PhD

Lineage Tracing

Lineage Tracing

Looking for the source of regenerated prostate luminal epithelial cells through lineage tracing. Fluorescence microscopy, original magnification 40x.

- Laura Pascal, PhD

Metastatic Adenocarcinoma

Metastatic Adenocarcinoma

Metastatic adenocarcinoma. Cytospin preparation with Diff Quik stain (magnification x400).

- Liron Pantanowitz, MD

NK Cell Attacking Cancer Cell

NK Cell Attacking Cancer Cell

NKs will go to great lengths to save us from Cancer.

- Per Basse, MD, PhD

CD8 T Cells Within Cancer Nests

CD8 T Cells Within Cancer Nests

Rare site to See: CD8 T cells within cancer nests in in Human colorectal tumor sample. Leica Spectral confocal microscope analysis at 63x.

- Ravikumar Muthuswamy, PhD

Andy Warhol Style Dendritic Cells

Andy Warhol Style Dendritic Cells

Dendritic cells from the hometown of Andy Warhol.

- Robbie Mailiiard, PhD

CD40L-Induced Morphological Changes

CD40L-Induced Morphological Changes

Confocal microscopy using IMARIS imaging software to analyze CD40L-induced morphological changes of a type-1 polarized dendritic cell (magnification 600X). Image taken by Colleen Zaccard, PhD.

- Robbie Mailiiard, PhD

Breast Cancer Genomic Changes

Breast Cancer Genomic Changes

Genomic changes acquired during metastatic breast cancer progression. Copy number variation, single nucleotide variants, and structural changes are shown for multiple metastatic tumors from one patient.

- Ryan Hartmaier, PhD

>MDA-MB-231 Breast Cancer Cell

>MDA-MB-231 Breast Cancer Cell

MDA-MB-231 breast cancer cell deficient in fission protein Drp1 was undergoing mitosis. Cell was stained with actin (red), mitochondria (green) and DNA (blue).

- Wei Qian, PhD

Molecules of XPA Protein

Molecules of XPA Protein

Single molecules of XPA protein bound to AAF lesions embedded in DNA. Atomic force microscopy, magnification 50,800x.

- Muwen Kong

Breast Cancer Tissue

Breast Cancer Tissue

Breast cancer tissue stained with anti-E-cadherin and anti-vimentin. Immunofluorescent microscopy, magnification 200x.

- Jieming Zhang

Metastatic Melanoma

Metastatic Melanoma

Metastatic melanoma. MelanA immunostain (magnification x400).

- Liron Pantanowitz, MD

Genomic Changes During Breast Cancer

Genomic Changes During Breast Cancer

Genomic changes acquired during metastatic breast cancer progression. Circos plots showing genomic changes acquired are overlaid on a patient PET scan from where tumors were obtained.

- Ryan Hartmaier, PhD

UV Exposed BJ-hTERT Skin Fibroblasts

UV Exposed BJ-hTERT Skin Fibroblasts

UV exposed BJ-hTERT skin fibroblasts deficient in nucleotide excision repair exhibit chromosome breakage and telomere aberrations 48h post exposure. DNA in blue; telomeres in green. Obj 60x

- Elise Fouquerel, PhD

HMLE-Twist Cells

HMLE-Twist Cells

HMLE-Twist cells stained with anti-CD108. Immunofluorescent microscopy, magnification 200x.

- Jieming Zhang

Mito Damage in MDA-MB-231 Cells

Mito Damage in MDA-MB-231 Cells

MDA-MB-231 cells exhibited mitochondria damage after mitochondria targeted photodynamic therapy (PDT). Upon PDT treatment, mitochondria turned into swelling and circle-like shape.

- Shaojuan Zhang, PhD